IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

The role of IFI16 as a DNA sensor is highly controversial. With support from a Nature Communications back-to-back publication from Almineet al. the authors here provide functional evidence that IFI16 is required for DNA sensing via the cGAS-STING pathway in human macrophages.

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Auteurs principaux:	K. L. Jønsson, A. Laustsen, C. Krapp, K. A. Skipper, K. Thavachelvam, D. Hotter, J. H. Egedal, M. Kjolby, P. Mohammadi, T. Prabakaran, L. K. Sørensen, C. Sun, S. B. Jensen, C. K. Holm, R. J. Lebbink, M. Johannsen, M. Nyegaard, J. G. Mikkelsen, F. Kirchhoff, S. R. Paludan, M. R. Jakobsen
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/f077d067175040ebb442e5ac090773d6
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IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

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