Motor cortical excitability predicts cognitive phenotypes in amyotrophic lateral sclerosis

Motor cortical excitability predicts cognitive phenotypes in amyotrophic lateral sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are well-recognised as an extended disease spectrum. This study hypothesised that cortical hyperexcitability, an early pathophysiological abnormality in ALS, would distinguish cognitive phenotypes, as a surrogate marker o...

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Main Authors: Smriti Agarwal, Elizabeth Highton-Williamson, Jashelle Caga, James Howells, Thanuja Dharmadasa, José M. Matamala, Yan Ma, Kazumoto Shibuya, John R. Hodges, Rebekah M. Ahmed, Steve Vucic, Matthew C. Kiernan
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/f078d7f7bedc4ed1b7dc8b9ca05c2cf6
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