Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus

Wnt proteins mediate embryonic development but how protein localization and patterning is regulated is unclear. Here, the authors show that distinct structures with different heparan sulfate modifications (‘N-sulfo-rich’ and ‘N-acetyl-rich’) regulate cellular localization and signal transduction of...

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Autores principales:	Yusuke Mii, Takayoshi Yamamoto, Ritsuko Takada, Shuji Mizumoto, Makoto Matsuyama, Shuhei Yamada, Shinji Takada, Masanori Taira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f0792f5891d54f889587aed241efe068
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spelling	oai:doaj.org-article:f0792f5891d54f889587aed241efe0682021-12-02T17:06:00ZRoles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus10.1038/s41467-017-02076-02041-1723https://doaj.org/article/f0792f5891d54f889587aed241efe0682017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02076-0https://doaj.org/toc/2041-1723Wnt proteins mediate embryonic development but how protein localization and patterning is regulated is unclear. Here, the authors show that distinct structures with different heparan sulfate modifications (‘N-sulfo-rich’ and ‘N-acetyl-rich’) regulate cellular localization and signal transduction of Wnt8 in Xenopus.Yusuke MiiTakayoshi YamamotoRitsuko TakadaShuji MizumotoMakoto MatsuyamaShuhei YamadaShinji TakadaMasanori TairaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yusuke Mii Takayoshi Yamamoto Ritsuko Takada Shuji Mizumoto Makoto Matsuyama Shuhei Yamada Shinji Takada Masanori Taira Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus
description	Wnt proteins mediate embryonic development but how protein localization and patterning is regulated is unclear. Here, the authors show that distinct structures with different heparan sulfate modifications (‘N-sulfo-rich’ and ‘N-acetyl-rich’) regulate cellular localization and signal transduction of Wnt8 in Xenopus.
format	article
author	Yusuke Mii Takayoshi Yamamoto Ritsuko Takada Shuji Mizumoto Makoto Matsuyama Shuhei Yamada Shinji Takada Masanori Taira
author_facet	Yusuke Mii Takayoshi Yamamoto Ritsuko Takada Shuji Mizumoto Makoto Matsuyama Shuhei Yamada Shinji Takada Masanori Taira
author_sort	Yusuke Mii
title	Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus
title_short	Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus
title_full	Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus
title_fullStr	Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus
title_full_unstemmed	Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus
title_sort	roles of two types of heparan sulfate clusters in wnt distribution and signaling in xenopus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f0792f5891d54f889587aed241efe068
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Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus

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