A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut.

A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut.

Malaria transmission-blocking (T-B) interventions are essential for malaria elimination. Small molecules that inhibit the Plasmodium ookinete-to-oocyst transition in the midgut of Anopheles mosquitoes, thereby blocking sporogony, represent one approach to achieving this goal. Chondroitin sulfate gly...

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Bibliographic Details
Main Authors: Derrick K Mathias, Rebecca Pastrana-Mena, Elisabetta Ranucci, Dingyin Tao, Paolo Ferruti, Corrie Ortega, Gregory O Staples, Joseph Zaia, Eizo Takashima, Takafumi Tsuboi, Natalie A Borg, Luisella Verotta, Rhoel R Dinglasan
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/f0829bc3f99e45feb075814ea5c92d22
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https://doaj.org/article/f0829bc3f99e45feb075814ea5c92d22

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