Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c
Mutations inCHCHD2 are associated with Parkinson’s disease. Here the authors investigate the physiological and pathological roles of CHCHD2 in Drosophilaand mammalian cells, and find that it regulates mitochondrial respiration through stabilizing cytochrome c.
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| Main Authors: | , , , , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2017
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| Subjects: | |
| Online Access: | https://doaj.org/article/f0f13ae34fb3421384e2c167bf51757f |
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