Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

Mutations inCHCHD2 are associated with Parkinson’s disease. Here the authors investigate the physiological and pathological roles of CHCHD2 in Drosophilaand mammalian cells, and find that it regulates mitochondrial respiration through stabilizing cytochrome c.

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Autores principales:	Hongrui Meng, Chikara Yamashita, Kahori Shiba-Fukushima, Tsuyoshi Inoshita, Manabu Funayama, Shigeto Sato, Tomohisa Hatta, Tohru Natsume, Masataka Umitsu, Junichi Takagi, Yuzuru Imai, Nobutaka Hattori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f0f13ae34fb3421384e2c167bf51757f
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spelling	oai:doaj.org-article:f0f13ae34fb3421384e2c167bf51757f2021-12-02T14:40:22ZLoss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c10.1038/ncomms155002041-1723https://doaj.org/article/f0f13ae34fb3421384e2c167bf51757f2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15500https://doaj.org/toc/2041-1723Mutations inCHCHD2 are associated with Parkinson’s disease. Here the authors investigate the physiological and pathological roles of CHCHD2 in Drosophilaand mammalian cells, and find that it regulates mitochondrial respiration through stabilizing cytochrome c.Hongrui MengChikara YamashitaKahori Shiba-FukushimaTsuyoshi InoshitaManabu FunayamaShigeto SatoTomohisa HattaTohru NatsumeMasataka UmitsuJunichi TakagiYuzuru ImaiNobutaka HattoriNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongrui Meng Chikara Yamashita Kahori Shiba-Fukushima Tsuyoshi Inoshita Manabu Funayama Shigeto Sato Tomohisa Hatta Tohru Natsume Masataka Umitsu Junichi Takagi Yuzuru Imai Nobutaka Hattori Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c
description	Mutations inCHCHD2 are associated with Parkinson’s disease. Here the authors investigate the physiological and pathological roles of CHCHD2 in Drosophilaand mammalian cells, and find that it regulates mitochondrial respiration through stabilizing cytochrome c.
format	article
author	Hongrui Meng Chikara Yamashita Kahori Shiba-Fukushima Tsuyoshi Inoshita Manabu Funayama Shigeto Sato Tomohisa Hatta Tohru Natsume Masataka Umitsu Junichi Takagi Yuzuru Imai Nobutaka Hattori
author_facet	Hongrui Meng Chikara Yamashita Kahori Shiba-Fukushima Tsuyoshi Inoshita Manabu Funayama Shigeto Sato Tomohisa Hatta Tohru Natsume Masataka Umitsu Junichi Takagi Yuzuru Imai Nobutaka Hattori
author_sort	Hongrui Meng
title	Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c
title_short	Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c
title_full	Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c
title_fullStr	Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c
title_full_unstemmed	Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c
title_sort	loss of parkinson’s disease-associated protein chchd2 affects mitochondrial crista structure and destabilizes cytochrome c
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f0f13ae34fb3421384e2c167bf51757f
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Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

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