Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis

Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis

The contribution of EMT in mammary gland homeostasis and human breast cancer is still unclear. Here, using in vivo lineage tracing and breast cancer PDXs the authors demonstrate that the repopulating capacity in normal mammary epithelial cells and tumorigenic capacity in breast cancer is independent...

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Main Authors: Shaheen S. Sikandar, Angera H. Kuo, Tomer Kalisky, Shang Cai, Maider Zabala, Robert W. Hsieh, Neethan A. Lobo, Ferenc A. Scheeren, Sopheak Sim, Dalong Qian, Frederick M. Dirbas, George Somlo, Stephen R. Quake, Michael F. Clarke
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/f0f50f3b3e2d42029e585ebb81c7168c
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Summary:The contribution of EMT in mammary gland homeostasis and human breast cancer is still unclear. Here, using in vivo lineage tracing and breast cancer PDXs the authors demonstrate that the repopulating capacity in normal mammary epithelial cells and tumorigenic capacity in breast cancer is independent of expression of EMT-associated genes.

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