Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis

The contribution of EMT in mammary gland homeostasis and human breast cancer is still unclear. Here, using in vivo lineage tracing and breast cancer PDXs the authors demonstrate that the repopulating capacity in normal mammary epithelial cells and tumorigenic capacity in breast cancer is independent...

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Main Authors:	Shaheen S. Sikandar, Angera H. Kuo, Tomer Kalisky, Shang Cai, Maider Zabala, Robert W. Hsieh, Neethan A. Lobo, Ferenc A. Scheeren, Sopheak Sim, Dalong Qian, Frederick M. Dirbas, George Somlo, Stephen R. Quake, Michael F. Clarke
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/f0f50f3b3e2d42029e585ebb81c7168c
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spelling	oai:doaj.org-article:f0f50f3b3e2d42029e585ebb81c7168c2021-12-02T15:39:00ZRole of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis10.1038/s41467-017-01666-22041-1723https://doaj.org/article/f0f50f3b3e2d42029e585ebb81c7168c2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01666-2https://doaj.org/toc/2041-1723The contribution of EMT in mammary gland homeostasis and human breast cancer is still unclear. Here, using in vivo lineage tracing and breast cancer PDXs the authors demonstrate that the repopulating capacity in normal mammary epithelial cells and tumorigenic capacity in breast cancer is independent of expression of EMT-associated genes.Shaheen S. SikandarAngera H. KuoTomer KaliskyShang CaiMaider ZabalaRobert W. HsiehNeethan A. LoboFerenc A. ScheerenSopheak SimDalong QianFrederick M. DirbasGeorge SomloStephen R. QuakeMichael F. ClarkeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shaheen S. Sikandar Angera H. Kuo Tomer Kalisky Shang Cai Maider Zabala Robert W. Hsieh Neethan A. Lobo Ferenc A. Scheeren Sopheak Sim Dalong Qian Frederick M. Dirbas George Somlo Stephen R. Quake Michael F. Clarke Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
description	The contribution of EMT in mammary gland homeostasis and human breast cancer is still unclear. Here, using in vivo lineage tracing and breast cancer PDXs the authors demonstrate that the repopulating capacity in normal mammary epithelial cells and tumorigenic capacity in breast cancer is independent of expression of EMT-associated genes.
format	article
author	Shaheen S. Sikandar Angera H. Kuo Tomer Kalisky Shang Cai Maider Zabala Robert W. Hsieh Neethan A. Lobo Ferenc A. Scheeren Sopheak Sim Dalong Qian Frederick M. Dirbas George Somlo Stephen R. Quake Michael F. Clarke
author_facet	Shaheen S. Sikandar Angera H. Kuo Tomer Kalisky Shang Cai Maider Zabala Robert W. Hsieh Neethan A. Lobo Ferenc A. Scheeren Sopheak Sim Dalong Qian Frederick M. Dirbas George Somlo Stephen R. Quake Michael F. Clarke
author_sort	Shaheen S. Sikandar
title	Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
title_short	Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
title_full	Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
title_fullStr	Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
title_full_unstemmed	Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
title_sort	role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f0f50f3b3e2d42029e585ebb81c7168c
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Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis

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