Slipknotted and unknotted monovalent cation-proton antiporters evolved from a common ancestor.

While the slipknot topology in proteins has been known for over a decade, its evolutionary origin is still a mystery. We have identified a previously overlooked slipknot motif in a family of two-domain membrane transporters. Moreover, we found that these proteins are homologous to several families o...

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Bibliographic Details
Main Authors: Vasilina Zayats, Agata P Perlinska, Aleksandra I Jarmolinska, Borys Jastrzebski, Stanislaw Dunin-Horkawicz, Joanna I Sulkowska
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
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Online Access:https://doaj.org/article/f105ce84f84c4826ad5083eca7f3d2ec
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