APOBEC3C Tandem Domain Proteins Create Super Restriction Factors against HIV-1

ABSTRACT Humans encode proteins, called restriction factors, that inhibit replication of viruses such as HIV-1. The members of one family of antiviral proteins, apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3; shortened here to A3), act by deaminating cytidines to uridines...

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Bibliographic Details
Main Authors: Mollie M. McDonnell, Kate H. D. Crawford, Adam S. Dingens, Jesse D. Bloom, Michael Emerman
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
Vif
Online Access:https://doaj.org/article/f1374489112c4b6484f89a474867ce79
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