Generation of orthotopically functional salivary gland from embryonic stem cells
Functional salivary glands have not been generated from embryonic stem cells (mESCs) to date. Here the authors demonstrate directed in vitro differentiation of mESCs to oral ectoderm and salivary gland rudiments that form mature, functional salivary glands after orthotopic transplantation.
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Nature Portfolio
2018
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oai:doaj.org-article:f148603a57a342e797646b37a7951c442021-12-02T14:40:43ZGeneration of orthotopically functional salivary gland from embryonic stem cells10.1038/s41467-018-06469-72041-1723https://doaj.org/article/f148603a57a342e797646b37a7951c442018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06469-7https://doaj.org/toc/2041-1723Functional salivary glands have not been generated from embryonic stem cells (mESCs) to date. Here the authors demonstrate directed in vitro differentiation of mESCs to oral ectoderm and salivary gland rudiments that form mature, functional salivary glands after orthotopic transplantation.Junichi TanakaMiho OgawaHironori HojoYusuke KawashimaYo MabuchiKenji HataShiro NakamuraRika YasuharaKoki TakamatsuTarou IriéToshiyuki FukadaTakayoshi SakaiTomio InoueRiko NishimuraOsamu OharaIchiro SaitoShinsuke OhbaTakashi TsujiKenji MishimaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Junichi Tanaka Miho Ogawa Hironori Hojo Yusuke Kawashima Yo Mabuchi Kenji Hata Shiro Nakamura Rika Yasuhara Koki Takamatsu Tarou Irié Toshiyuki Fukada Takayoshi Sakai Tomio Inoue Riko Nishimura Osamu Ohara Ichiro Saito Shinsuke Ohba Takashi Tsuji Kenji Mishima Generation of orthotopically functional salivary gland from embryonic stem cells |
| description |
Functional salivary glands have not been generated from embryonic stem cells (mESCs) to date. Here the authors demonstrate directed in vitro differentiation of mESCs to oral ectoderm and salivary gland rudiments that form mature, functional salivary glands after orthotopic transplantation. |
| format |
article |
| author |
Junichi Tanaka Miho Ogawa Hironori Hojo Yusuke Kawashima Yo Mabuchi Kenji Hata Shiro Nakamura Rika Yasuhara Koki Takamatsu Tarou Irié Toshiyuki Fukada Takayoshi Sakai Tomio Inoue Riko Nishimura Osamu Ohara Ichiro Saito Shinsuke Ohba Takashi Tsuji Kenji Mishima |
| author_facet |
Junichi Tanaka Miho Ogawa Hironori Hojo Yusuke Kawashima Yo Mabuchi Kenji Hata Shiro Nakamura Rika Yasuhara Koki Takamatsu Tarou Irié Toshiyuki Fukada Takayoshi Sakai Tomio Inoue Riko Nishimura Osamu Ohara Ichiro Saito Shinsuke Ohba Takashi Tsuji Kenji Mishima |
| author_sort |
Junichi Tanaka |
| title |
Generation of orthotopically functional salivary gland from embryonic stem cells |
| title_short |
Generation of orthotopically functional salivary gland from embryonic stem cells |
| title_full |
Generation of orthotopically functional salivary gland from embryonic stem cells |
| title_fullStr |
Generation of orthotopically functional salivary gland from embryonic stem cells |
| title_full_unstemmed |
Generation of orthotopically functional salivary gland from embryonic stem cells |
| title_sort |
generation of orthotopically functional salivary gland from embryonic stem cells |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/f148603a57a342e797646b37a7951c44 |
| work_keys_str_mv |
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