Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45

Malaria protein Pfs48/45 is a promising transmission-blocking antigen targeted by antibodies. Here, the authors determine the structure of its transmission-blocking epitope I, and generate a humanized monoclonal antibody that binds Pfs48/45 with high affinity.

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Autores principales: Prasun Kundu, Anthony Semesi, Matthijs M. Jore, Merribeth J. Morin, Virginia L. Price, Alice Liang, Jingxing Li, Kazutoyo Miura, Robert W. Sauerwein, C. Richter King, Jean-Philippe Julien
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Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/f164d6aeda444b7184cfe6f2d8f3cc0d
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spelling oai:doaj.org-article:f164d6aeda444b7184cfe6f2d8f3cc0d2021-12-02T16:49:24ZStructural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/4510.1038/s41467-018-06742-92041-1723https://doaj.org/article/f164d6aeda444b7184cfe6f2d8f3cc0d2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06742-9https://doaj.org/toc/2041-1723Malaria protein Pfs48/45 is a promising transmission-blocking antigen targeted by antibodies. Here, the authors determine the structure of its transmission-blocking epitope I, and generate a humanized monoclonal antibody that binds Pfs48/45 with high affinity.Prasun KunduAnthony SemesiMatthijs M. JoreMerribeth J. MorinVirginia L. PriceAlice LiangJingxing LiKazutoyo MiuraRobert W. SauerweinC. Richter KingJean-Philippe JulienNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Prasun Kundu
Anthony Semesi
Matthijs M. Jore
Merribeth J. Morin
Virginia L. Price
Alice Liang
Jingxing Li
Kazutoyo Miura
Robert W. Sauerwein
C. Richter King
Jean-Philippe Julien
Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45
description Malaria protein Pfs48/45 is a promising transmission-blocking antigen targeted by antibodies. Here, the authors determine the structure of its transmission-blocking epitope I, and generate a humanized monoclonal antibody that binds Pfs48/45 with high affinity.
format article
author Prasun Kundu
Anthony Semesi
Matthijs M. Jore
Merribeth J. Morin
Virginia L. Price
Alice Liang
Jingxing Li
Kazutoyo Miura
Robert W. Sauerwein
C. Richter King
Jean-Philippe Julien
author_facet Prasun Kundu
Anthony Semesi
Matthijs M. Jore
Merribeth J. Morin
Virginia L. Price
Alice Liang
Jingxing Li
Kazutoyo Miura
Robert W. Sauerwein
C. Richter King
Jean-Philippe Julien
author_sort Prasun Kundu
title Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45
title_short Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45
title_full Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45
title_fullStr Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45
title_full_unstemmed Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45
title_sort structural delineation of potent transmission-blocking epitope i on malaria antigen pfs48/45
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/f164d6aeda444b7184cfe6f2d8f3cc0d
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