Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45

Malaria protein Pfs48/45 is a promising transmission-blocking antigen targeted by antibodies. Here, the authors determine the structure of its transmission-blocking epitope I, and generate a humanized monoclonal antibody that binds Pfs48/45 with high affinity.

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Auteurs principaux:	Prasun Kundu, Anthony Semesi, Matthijs M. Jore, Merribeth J. Morin, Virginia L. Price, Alice Liang, Jingxing Li, Kazutoyo Miura, Robert W. Sauerwein, C. Richter King, Jean-Philippe Julien
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/f164d6aeda444b7184cfe6f2d8f3cc0d
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spelling	oai:doaj.org-article:f164d6aeda444b7184cfe6f2d8f3cc0d2021-12-02T16:49:24ZStructural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/4510.1038/s41467-018-06742-92041-1723https://doaj.org/article/f164d6aeda444b7184cfe6f2d8f3cc0d2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06742-9https://doaj.org/toc/2041-1723Malaria protein Pfs48/45 is a promising transmission-blocking antigen targeted by antibodies. Here, the authors determine the structure of its transmission-blocking epitope I, and generate a humanized monoclonal antibody that binds Pfs48/45 with high affinity.Prasun KunduAnthony SemesiMatthijs M. JoreMerribeth J. MorinVirginia L. PriceAlice LiangJingxing LiKazutoyo MiuraRobert W. SauerweinC. Richter KingJean-Philippe JulienNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Prasun Kundu Anthony Semesi Matthijs M. Jore Merribeth J. Morin Virginia L. Price Alice Liang Jingxing Li Kazutoyo Miura Robert W. Sauerwein C. Richter King Jean-Philippe Julien Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45
description	Malaria protein Pfs48/45 is a promising transmission-blocking antigen targeted by antibodies. Here, the authors determine the structure of its transmission-blocking epitope I, and generate a humanized monoclonal antibody that binds Pfs48/45 with high affinity.
format	article
author	Prasun Kundu Anthony Semesi Matthijs M. Jore Merribeth J. Morin Virginia L. Price Alice Liang Jingxing Li Kazutoyo Miura Robert W. Sauerwein C. Richter King Jean-Philippe Julien
author_facet	Prasun Kundu Anthony Semesi Matthijs M. Jore Merribeth J. Morin Virginia L. Price Alice Liang Jingxing Li Kazutoyo Miura Robert W. Sauerwein C. Richter King Jean-Philippe Julien
author_sort	Prasun Kundu
title	Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45
title_short	Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45
title_full	Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45
title_fullStr	Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45
title_full_unstemmed	Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45
title_sort	structural delineation of potent transmission-blocking epitope i on malaria antigen pfs48/45
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f164d6aeda444b7184cfe6f2d8f3cc0d
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Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45

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