Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45
Malaria protein Pfs48/45 is a promising transmission-blocking antigen targeted by antibodies. Here, the authors determine the structure of its transmission-blocking epitope I, and generate a humanized monoclonal antibody that binds Pfs48/45 with high affinity.
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Nature Portfolio
2018
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oai:doaj.org-article:f164d6aeda444b7184cfe6f2d8f3cc0d2021-12-02T16:49:24ZStructural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/4510.1038/s41467-018-06742-92041-1723https://doaj.org/article/f164d6aeda444b7184cfe6f2d8f3cc0d2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06742-9https://doaj.org/toc/2041-1723Malaria protein Pfs48/45 is a promising transmission-blocking antigen targeted by antibodies. Here, the authors determine the structure of its transmission-blocking epitope I, and generate a humanized monoclonal antibody that binds Pfs48/45 with high affinity.Prasun KunduAnthony SemesiMatthijs M. JoreMerribeth J. MorinVirginia L. PriceAlice LiangJingxing LiKazutoyo MiuraRobert W. SauerweinC. Richter KingJean-Philippe JulienNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018) |
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EN |
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Science Q |
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Science Q Prasun Kundu Anthony Semesi Matthijs M. Jore Merribeth J. Morin Virginia L. Price Alice Liang Jingxing Li Kazutoyo Miura Robert W. Sauerwein C. Richter King Jean-Philippe Julien Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45 |
description |
Malaria protein Pfs48/45 is a promising transmission-blocking antigen targeted by antibodies. Here, the authors determine the structure of its transmission-blocking epitope I, and generate a humanized monoclonal antibody that binds Pfs48/45 with high affinity. |
format |
article |
author |
Prasun Kundu Anthony Semesi Matthijs M. Jore Merribeth J. Morin Virginia L. Price Alice Liang Jingxing Li Kazutoyo Miura Robert W. Sauerwein C. Richter King Jean-Philippe Julien |
author_facet |
Prasun Kundu Anthony Semesi Matthijs M. Jore Merribeth J. Morin Virginia L. Price Alice Liang Jingxing Li Kazutoyo Miura Robert W. Sauerwein C. Richter King Jean-Philippe Julien |
author_sort |
Prasun Kundu |
title |
Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45 |
title_short |
Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45 |
title_full |
Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45 |
title_fullStr |
Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45 |
title_full_unstemmed |
Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45 |
title_sort |
structural delineation of potent transmission-blocking epitope i on malaria antigen pfs48/45 |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/f164d6aeda444b7184cfe6f2d8f3cc0d |
work_keys_str_mv |
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1718383371751522304 |