Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

Remdesivir (RDV) is a broad-spectrum antiviral drug with activity against MERS coronavirus, but in vivo efficacy has not been evaluated. Here, the authors show that RDV has superior anti-MERS activity in vitro and in vivo compared to combination therapy with lopinavir, ritonavir and interferon beta...

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Autores principales:	Timothy P. Sheahan, Amy C. Sims, Sarah R. Leist, Alexandra Schäfer, John Won, Ariane J. Brown, Stephanie A. Montgomery, Alison Hogg, Darius Babusis, Michael O. Clarke, Jamie E. Spahn, Laura Bauer, Scott Sellers, Danielle Porter, Joy Y. Feng, Tomas Cihlar, Robert Jordan, Mark R. Denison, Ralph S. Baric
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f17353d0fecb47bb853401bd79786ace
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spelling	oai:doaj.org-article:f17353d0fecb47bb853401bd79786ace2021-12-02T14:40:52ZComparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV10.1038/s41467-019-13940-62041-1723https://doaj.org/article/f17353d0fecb47bb853401bd79786ace2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13940-6https://doaj.org/toc/2041-1723Remdesivir (RDV) is a broad-spectrum antiviral drug with activity against MERS coronavirus, but in vivo efficacy has not been evaluated. Here, the authors show that RDV has superior anti-MERS activity in vitro and in vivo compared to combination therapy with lopinavir, ritonavir and interferon beta and reduces severe lung pathology.Timothy P. SheahanAmy C. SimsSarah R. LeistAlexandra SchäferJohn WonAriane J. BrownStephanie A. MontgomeryAlison HoggDarius BabusisMichael O. ClarkeJamie E. SpahnLaura BauerScott SellersDanielle PorterJoy Y. FengTomas CihlarRobert JordanMark R. DenisonRalph S. BaricNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Timothy P. Sheahan Amy C. Sims Sarah R. Leist Alexandra Schäfer John Won Ariane J. Brown Stephanie A. Montgomery Alison Hogg Darius Babusis Michael O. Clarke Jamie E. Spahn Laura Bauer Scott Sellers Danielle Porter Joy Y. Feng Tomas Cihlar Robert Jordan Mark R. Denison Ralph S. Baric Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
description	Remdesivir (RDV) is a broad-spectrum antiviral drug with activity against MERS coronavirus, but in vivo efficacy has not been evaluated. Here, the authors show that RDV has superior anti-MERS activity in vitro and in vivo compared to combination therapy with lopinavir, ritonavir and interferon beta and reduces severe lung pathology.
format	article
author	Timothy P. Sheahan Amy C. Sims Sarah R. Leist Alexandra Schäfer John Won Ariane J. Brown Stephanie A. Montgomery Alison Hogg Darius Babusis Michael O. Clarke Jamie E. Spahn Laura Bauer Scott Sellers Danielle Porter Joy Y. Feng Tomas Cihlar Robert Jordan Mark R. Denison Ralph S. Baric
author_facet	Timothy P. Sheahan Amy C. Sims Sarah R. Leist Alexandra Schäfer John Won Ariane J. Brown Stephanie A. Montgomery Alison Hogg Darius Babusis Michael O. Clarke Jamie E. Spahn Laura Bauer Scott Sellers Danielle Porter Joy Y. Feng Tomas Cihlar Robert Jordan Mark R. Denison Ralph S. Baric
author_sort	Timothy P. Sheahan
title	Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
title_short	Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
title_full	Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
title_fullStr	Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
title_full_unstemmed	Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
title_sort	comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against mers-cov
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f17353d0fecb47bb853401bd79786ace
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Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

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