Exploring the Association Between Demographics, SLC30A8 Genotype, and Human Islet Content of Zinc, Cadmium, Copper, Iron, Manganese and Nickel

Abstract A widely prevalent single nucleotide polymorphism, rs13266634 in the SLC30A8 gene encoding the zinc transporter ZnT8, is associated with an increased risk for T2DM. ZnT8 is mostly expressed in pancreatic insulin-producing islets of Langerhans. The effect of this variant on the divalent meta...

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Autores principales: Winifred P. Wong, Norrina B. Allen, Matthew S. Meyers, Emma O. Link, Xiaomin Zhang, Keith W. MacRenaris, Malek El Muayed
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/f182595b63d2455bb3ab52db6da0c370
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