Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid -- a meta-analysis of randomised and observational trials of over 30.000 patients.

<h4>Background</h4>To compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and ε-aminocaproic acid) on early mortality in three subgroups of patients: low, intermediate and high risk of cardiac surgery.<h4>Methods and findings</h4>We performed...

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Bibliographic Details
Main Authors: Patrick Meybohm, Eva Herrmann, Julia Nierhoff, Kai Zacharowski
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
R
Q
Online Access:https://doaj.org/article/f1e29d4fe4e54ee89eea77d10db35d23
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