Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Diabetes is characterized by prolonged hyperglycaemia and tissue damage in pancreatic islets. Here, Brereton et al. show that chronic high glucose levels lead to glycogen accumulation in β-cells, associated with reduced autophagy, impaired metabolism, insulin granule depletion and apoptosis.

Saved in:
Bibliographic Details
Main Authors: Melissa F. Brereton, Maria Rohm, Kenju Shimomura, Christian Holland, Sharona Tornovsky-Babeay, Daniela Dadon, Michaela Iberl, Margarita V. Chibalina, Sheena Lee, Benjamin Glaser, Yuval Dor, Patrik Rorsman, Anne Clark, Frances M. Ashcroft
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/f1f19a27cbc7439a93582c5ddb593cd1
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/f1f19a27cbc7439a93582c5ddb593cd1

Similar Items