Characterization of Recombinant Chimpanzee Adenovirus C68 Low and High-Density Particles: Impact on Determination of Viral Particle Titer

Characterization of Recombinant Chimpanzee Adenovirus C68 Low and High-Density Particles: Impact on Determination of Viral Particle Titer

We observed differential infectivity and product yield between two recombinant chimpanzee adenovirus C68 constructs whose primary difference was genome length. To determine a possible reason for this outcome, we characterized the proportion and composition of the empty and packaged capsids. Both ana...

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Autores principales: Elise K. Mullins, Thomas W. Powers, Jim Zobel, Kory M. Clawson, Lauren F. Barnes, Benjamin E. Draper, Qin Zou, Joseph J. Binder, Stanley Dai, Kun Zhang, Olga Friese, Herbert A. Runnels, Martin F. Jarrold, Lawrence C. Thompson
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
non-human primate
adenovirus
AEX-HPLC
analytical ultracentrifugation
differential centrifugation sedimentation
charge detection mass spectrometry
Biotechnology
TP248.13-248.65
Acceso en línea:https://doaj.org/article/f1f1e75dde024640af7aecb78aac433e
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https://doaj.org/article/f1f1e75dde024640af7aecb78aac433e

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