Modulation of FLT3-ITD Localization and Targeting of Distinct Downstream Signaling Pathways as Potential Strategies to Overcome FLT3-Inhibitor Resistance

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Modulation of FLT3-ITD Localization and Targeting of Distinct Downstream Signaling Pathways as Potential Strategies to Overcome FLT3-Inhibitor Resistance

OBJECTIVES: Internal tandem duplications (ITDs) of the Fms-like tyrosine kinase 3 (FLT3) represent the most frequent molecular aberrations in acute myeloid leukemia (AML) and are associated with an inferior prognosis. The pattern of downstream activation by this constitutively activated receptor tyr...

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Auteurs principaux:	Maximilian Fleischmann, Mike Fischer, Ulf Schnetzke, Colin Fortner, Joanna Kirkpatrick, Florian H. Heidel, Andreas Hochhaus, Sebastian Scholl
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	AML FLT3-ITD HSP90 tunicamycin 17-AAG VPA Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/f1f3d0de94324f91b33d1ea4ce8bcb3d
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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