Mmp12 Is Upregulated by in utero Second-Hand Smoke Exposures and Is a Key Factor Contributing to Aggravated Lung Responses in Adult Emphysema, Asthma, and Lung Cancer Mouse Models

Mmp12 Is Upregulated by in utero Second-Hand Smoke Exposures and Is a Key Factor Contributing to Aggravated Lung Responses in Adult Emphysema, Asthma, and Lung Cancer Mouse Models

Matrix metalloproteinase-12 (Mmp12) is upregulated by cigarette smoke (CS) and plays a critical role in extracellular matrix remodeling, a key mechanism involved in physiological repair processes, and in the pathogenesis of emphysema, asthma, and lung cancer. While cigarette smoking is associated wi...

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Bibliographic Details
Main Authors: Alexandra Noël, Zakia Perveen, Rui Xiao, Harriet Hammond, Viviana Le Donne, Kelsey Legendre, Manas Ranjan Gartia, Sushant Sahu, Daniel B. Paulsen, Arthur L. Penn
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
second-hand smoke
in utero exposures/prenatal exposures
Mmp12
emphysema
asthma
lung cancer
Physiology
QP1-981
Online Access:https://doaj.org/article/f1f997c1bb574fe680338bd60eca1640
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https://doaj.org/article/f1f997c1bb574fe680338bd60eca1640

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