Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

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Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

Tumours that are deficient in mismatch-repair genes should, in theory, have higher evolvability. Here, the authors explore this theory in gastro-oesophageal tumours.

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Bibliographic Details
Main Authors:	Katharina von Loga, Andrew Woolston, Marco Punta, Louise J. Barber, Beatrice Griffiths, Maria Semiannikova, Georgia Spain, Benjamin Challoner, Kerry Fenwick, Ronald Simon, Andreas Marx, Guido Sauter, Stefano Lise, Nik Matthews, Marco Gerlinger
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/f202e0a95a5045ca81301d8ebb687ecf
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Description
Summary:	Tumours that are deficient in mismatch-repair genes should, in theory, have higher evolvability. Here, the authors explore this theory in gastro-oesophageal tumours.