Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

Tumours that are deficient in mismatch-repair genes should, in theory, have higher evolvability. Here, the authors explore this theory in gastro-oesophageal tumours.

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Autores principales:	Katharina von Loga, Andrew Woolston, Marco Punta, Louise J. Barber, Beatrice Griffiths, Maria Semiannikova, Georgia Spain, Benjamin Challoner, Kerry Fenwick, Ronald Simon, Andreas Marx, Guido Sauter, Stefano Lise, Nik Matthews, Marco Gerlinger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f202e0a95a5045ca81301d8ebb687ecf
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spelling	oai:doaj.org-article:f202e0a95a5045ca81301d8ebb687ecf2021-12-02T13:24:34ZExtreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer10.1038/s41467-019-13915-72041-1723https://doaj.org/article/f202e0a95a5045ca81301d8ebb687ecf2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13915-7https://doaj.org/toc/2041-1723Tumours that are deficient in mismatch-repair genes should, in theory, have higher evolvability. Here, the authors explore this theory in gastro-oesophageal tumours.Katharina von LogaAndrew WoolstonMarco PuntaLouise J. BarberBeatrice GriffithsMaria SemiannikovaGeorgia SpainBenjamin ChallonerKerry FenwickRonald SimonAndreas MarxGuido SauterStefano LiseNik MatthewsMarco GerlingerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katharina von Loga Andrew Woolston Marco Punta Louise J. Barber Beatrice Griffiths Maria Semiannikova Georgia Spain Benjamin Challoner Kerry Fenwick Ronald Simon Andreas Marx Guido Sauter Stefano Lise Nik Matthews Marco Gerlinger Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
description	Tumours that are deficient in mismatch-repair genes should, in theory, have higher evolvability. Here, the authors explore this theory in gastro-oesophageal tumours.
format	article
author	Katharina von Loga Andrew Woolston Marco Punta Louise J. Barber Beatrice Griffiths Maria Semiannikova Georgia Spain Benjamin Challoner Kerry Fenwick Ronald Simon Andreas Marx Guido Sauter Stefano Lise Nik Matthews Marco Gerlinger
author_facet	Katharina von Loga Andrew Woolston Marco Punta Louise J. Barber Beatrice Griffiths Maria Semiannikova Georgia Spain Benjamin Challoner Kerry Fenwick Ronald Simon Andreas Marx Guido Sauter Stefano Lise Nik Matthews Marco Gerlinger
author_sort	Katharina von Loga
title	Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
title_short	Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
title_full	Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
title_fullStr	Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
title_full_unstemmed	Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
title_sort	extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f202e0a95a5045ca81301d8ebb687ecf
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Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

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