Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration

Proteasomal overload can be found in a broad spectrum of mouse models of retinal degeneration. Here the authors find that overexpressing the PA28α subunit of the 11S proteasome cap increased the number of surviving functional photoreceptor cells in a mouse model of retinal degeneration bearing the P...

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Autores principales:	Ekaterina S. Lobanova, Stella Finkelstein, Jing Li, Amanda M. Travis, Ying Hao, Mikael Klingeborn, Nikolai P. Skiba, Raymond J. Deshaies, Vadim Y. Arshavsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f205dd40283c431b8415d04bab375e77
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spelling	oai:doaj.org-article:f205dd40283c431b8415d04bab375e772021-12-02T15:34:28ZIncreased proteasomal activity supports photoreceptor survival in inherited retinal degeneration10.1038/s41467-018-04117-82041-1723https://doaj.org/article/f205dd40283c431b8415d04bab375e772018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04117-8https://doaj.org/toc/2041-1723Proteasomal overload can be found in a broad spectrum of mouse models of retinal degeneration. Here the authors find that overexpressing the PA28α subunit of the 11S proteasome cap increased the number of surviving functional photoreceptor cells in a mouse model of retinal degeneration bearing the P23H mutation in rhodopsin.Ekaterina S. LobanovaStella FinkelsteinJing LiAmanda M. TravisYing HaoMikael KlingebornNikolai P. SkibaRaymond J. DeshaiesVadim Y. ArshavskyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ekaterina S. Lobanova Stella Finkelstein Jing Li Amanda M. Travis Ying Hao Mikael Klingeborn Nikolai P. Skiba Raymond J. Deshaies Vadim Y. Arshavsky Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration
description	Proteasomal overload can be found in a broad spectrum of mouse models of retinal degeneration. Here the authors find that overexpressing the PA28α subunit of the 11S proteasome cap increased the number of surviving functional photoreceptor cells in a mouse model of retinal degeneration bearing the P23H mutation in rhodopsin.
format	article
author	Ekaterina S. Lobanova Stella Finkelstein Jing Li Amanda M. Travis Ying Hao Mikael Klingeborn Nikolai P. Skiba Raymond J. Deshaies Vadim Y. Arshavsky
author_facet	Ekaterina S. Lobanova Stella Finkelstein Jing Li Amanda M. Travis Ying Hao Mikael Klingeborn Nikolai P. Skiba Raymond J. Deshaies Vadim Y. Arshavsky
author_sort	Ekaterina S. Lobanova
title	Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration
title_short	Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration
title_full	Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration
title_fullStr	Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration
title_full_unstemmed	Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration
title_sort	increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f205dd40283c431b8415d04bab375e77
work_keys_str_mv	AT ekaterinaslobanova increasedproteasomalactivitysupportsphotoreceptorsurvivalininheritedretinaldegeneration AT stellafinkelstein increasedproteasomalactivitysupportsphotoreceptorsurvivalininheritedretinaldegeneration AT jingli increasedproteasomalactivitysupportsphotoreceptorsurvivalininheritedretinaldegeneration AT amandamtravis increasedproteasomalactivitysupportsphotoreceptorsurvivalininheritedretinaldegeneration AT yinghao increasedproteasomalactivitysupportsphotoreceptorsurvivalininheritedretinaldegeneration AT mikaelklingeborn increasedproteasomalactivitysupportsphotoreceptorsurvivalininheritedretinaldegeneration AT nikolaipskiba increasedproteasomalactivitysupportsphotoreceptorsurvivalininheritedretinaldegeneration AT raymondjdeshaies increasedproteasomalactivitysupportsphotoreceptorsurvivalininheritedretinaldegeneration AT vadimyarshavsky increasedproteasomalactivitysupportsphotoreceptorsurvivalininheritedretinaldegeneration
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Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration

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