Allosteric regulation alters carrier domain translocation in pyruvate carboxylase

Carrier domain enzymes accomplish catalysis by physically transporting intermediates long distances between remote active sites. Here the authors describe a wide range of catalytically productive translocation events during catalysis by pyruvate carboxylase and suggest a basis for its allosteric act...

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Autores principales:	Yumeng Liu, Melissa M. Budelier, Katelyn Stine, Martin St. Maurice
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f20adbd1481345a5b5a09bf6377d2d67
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spelling	oai:doaj.org-article:f20adbd1481345a5b5a09bf6377d2d672021-12-02T15:34:28ZAllosteric regulation alters carrier domain translocation in pyruvate carboxylase10.1038/s41467-018-03814-82041-1723https://doaj.org/article/f20adbd1481345a5b5a09bf6377d2d672018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03814-8https://doaj.org/toc/2041-1723Carrier domain enzymes accomplish catalysis by physically transporting intermediates long distances between remote active sites. Here the authors describe a wide range of catalytically productive translocation events during catalysis by pyruvate carboxylase and suggest a basis for its allosteric activation.Yumeng LiuMelissa M. BudelierKatelyn StineMartin St. MauriceNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yumeng Liu Melissa M. Budelier Katelyn Stine Martin St. Maurice Allosteric regulation alters carrier domain translocation in pyruvate carboxylase
description	Carrier domain enzymes accomplish catalysis by physically transporting intermediates long distances between remote active sites. Here the authors describe a wide range of catalytically productive translocation events during catalysis by pyruvate carboxylase and suggest a basis for its allosteric activation.
format	article
author	Yumeng Liu Melissa M. Budelier Katelyn Stine Martin St. Maurice
author_facet	Yumeng Liu Melissa M. Budelier Katelyn Stine Martin St. Maurice
author_sort	Yumeng Liu
title	Allosteric regulation alters carrier domain translocation in pyruvate carboxylase
title_short	Allosteric regulation alters carrier domain translocation in pyruvate carboxylase
title_full	Allosteric regulation alters carrier domain translocation in pyruvate carboxylase
title_fullStr	Allosteric regulation alters carrier domain translocation in pyruvate carboxylase
title_full_unstemmed	Allosteric regulation alters carrier domain translocation in pyruvate carboxylase
title_sort	allosteric regulation alters carrier domain translocation in pyruvate carboxylase
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f20adbd1481345a5b5a09bf6377d2d67
work_keys_str_mv	AT yumengliu allostericregulationalterscarrierdomaintranslocationinpyruvatecarboxylase AT melissambudelier allostericregulationalterscarrierdomaintranslocationinpyruvatecarboxylase AT katelynstine allostericregulationalterscarrierdomaintranslocationinpyruvatecarboxylase AT martinstmaurice allostericregulationalterscarrierdomaintranslocationinpyruvatecarboxylase
_version_	1718386876732145664

Allosteric regulation alters carrier domain translocation in pyruvate carboxylase

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