Positive and strongly relaxed purifying selection drive the evolution of repeats in proteins

Protein repeats may be considered a paradox, being evolutionarily conserved yet also hotspots of protein evolution associated with innovation. Here, the authors use a novel method to show that new repeats undergo rapid divergence within species, but are then fixed and conserved between species.

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Auteurs principaux: Erez Persi, Yuri I. Wolf, Eugene V Koonin
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/f21094ba5e1f44e5a9b02459431657e9
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