NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy

Pericytes are perivascular cells that regulate blood vessel formation and function. Here Dubrac et al. show that pericyte recruitment contributes to pathological neovascularisation in a mouse model of ischemic retinopathy, and that this depends on the regulation of PDGF-B signaling by NCK adaptor pr...

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Autores principales:	Alexandre Dubrac, Steffen E. Künzel, Sandrine H. Künzel, Jinyu Li, Rachana Radhamani Chandran, Kathleen Martin, Daniel M. Greif, Ralf H. Adams, Anne Eichmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f212c5aa389b4f57a14e393ebd8caa17
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spelling	oai:doaj.org-article:f212c5aa389b4f57a14e393ebd8caa172021-12-02T16:50:12ZNCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy10.1038/s41467-018-05926-72041-1723https://doaj.org/article/f212c5aa389b4f57a14e393ebd8caa172018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05926-7https://doaj.org/toc/2041-1723Pericytes are perivascular cells that regulate blood vessel formation and function. Here Dubrac et al. show that pericyte recruitment contributes to pathological neovascularisation in a mouse model of ischemic retinopathy, and that this depends on the regulation of PDGF-B signaling by NCK adaptor proteins.Alexandre DubracSteffen E. KünzelSandrine H. KünzelJinyu LiRachana Radhamani ChandranKathleen MartinDaniel M. GreifRalf H. AdamsAnne EichmannNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexandre Dubrac Steffen E. Künzel Sandrine H. Künzel Jinyu Li Rachana Radhamani Chandran Kathleen Martin Daniel M. Greif Ralf H. Adams Anne Eichmann NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
description	Pericytes are perivascular cells that regulate blood vessel formation and function. Here Dubrac et al. show that pericyte recruitment contributes to pathological neovascularisation in a mouse model of ischemic retinopathy, and that this depends on the regulation of PDGF-B signaling by NCK adaptor proteins.
format	article
author	Alexandre Dubrac Steffen E. Künzel Sandrine H. Künzel Jinyu Li Rachana Radhamani Chandran Kathleen Martin Daniel M. Greif Ralf H. Adams Anne Eichmann
author_facet	Alexandre Dubrac Steffen E. Künzel Sandrine H. Künzel Jinyu Li Rachana Radhamani Chandran Kathleen Martin Daniel M. Greif Ralf H. Adams Anne Eichmann
author_sort	Alexandre Dubrac
title	NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
title_short	NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
title_full	NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
title_fullStr	NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
title_full_unstemmed	NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
title_sort	nck-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f212c5aa389b4f57a14e393ebd8caa17
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NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy

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