Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish

Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish

Haematopoietic stem and progenitor cells (HSPCs) produce all blood lineages and arise from the haemogenic endothelium (HE) during embryogenesis. Here the authors show that genes specific to cilia formation are required for HSPC development in the HE in zebrafish through transduction of Notch signal.

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Bibliographic Details
Main Authors: Zhibin Liu, Haiqing Tu, Yunsi Kang, Yuanyuan Xue, Dongyuan Ma, Chengtian Zhao, Huiyan Li, Lu Wang, Feng Liu
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
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Online Access:https://doaj.org/article/f2213d7514cf44c29cd6ceee2cafd23a
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