Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids

Brain organoids are important tools to study early development and disease but little is known of their network activity and plasticity. Here the authors generate iPSC-derived neuronal organoids that display early network formation and maturation with evidence for a GABA polarity switch and long-ter...

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Autores principales:	Maria-Patapia Zafeiriou, Guobin Bao, James Hudson, Rashi Halder, Alica Blenkle, Marie-Kristin Schreiber, Andre Fischer, Detlev Schild, Wolfram-Hubertus Zimmermann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f2273b0bcbe64fb79978e872f203e52e
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spelling	oai:doaj.org-article:f2273b0bcbe64fb79978e872f203e52e2021-12-02T18:47:02ZDevelopmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids10.1038/s41467-020-17521-w2041-1723https://doaj.org/article/f2273b0bcbe64fb79978e872f203e52e2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17521-whttps://doaj.org/toc/2041-1723Brain organoids are important tools to study early development and disease but little is known of their network activity and plasticity. Here the authors generate iPSC-derived neuronal organoids that display early network formation and maturation with evidence for a GABA polarity switch and long-term potentiation.Maria-Patapia ZafeiriouGuobin BaoJames HudsonRashi HalderAlica BlenkleMarie-Kristin SchreiberAndre FischerDetlev SchildWolfram-Hubertus ZimmermannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria-Patapia Zafeiriou Guobin Bao James Hudson Rashi Halder Alica Blenkle Marie-Kristin Schreiber Andre Fischer Detlev Schild Wolfram-Hubertus Zimmermann Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
description	Brain organoids are important tools to study early development and disease but little is known of their network activity and plasticity. Here the authors generate iPSC-derived neuronal organoids that display early network formation and maturation with evidence for a GABA polarity switch and long-term potentiation.
format	article
author	Maria-Patapia Zafeiriou Guobin Bao James Hudson Rashi Halder Alica Blenkle Marie-Kristin Schreiber Andre Fischer Detlev Schild Wolfram-Hubertus Zimmermann
author_facet	Maria-Patapia Zafeiriou Guobin Bao James Hudson Rashi Halder Alica Blenkle Marie-Kristin Schreiber Andre Fischer Detlev Schild Wolfram-Hubertus Zimmermann
author_sort	Maria-Patapia Zafeiriou
title	Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
title_short	Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
title_full	Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
title_fullStr	Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
title_full_unstemmed	Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
title_sort	developmental gaba polarity switch and neuronal plasticity in bioengineered neuronal organoids
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f2273b0bcbe64fb79978e872f203e52e
work_keys_str_mv	AT mariapatapiazafeiriou developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids AT guobinbao developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids AT jameshudson developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids AT rashihalder developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids AT alicablenkle developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids AT mariekristinschreiber developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids AT andrefischer developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids AT detlevschild developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids AT wolframhubertuszimmermann developmentalgabapolarityswitchandneuronalplasticityinbioengineeredneuronalorganoids
_version_	1718377715518668800

Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids

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