Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease

Abstract Iron accumulates gradually in the ageing brain. In Parkinson’s disease, iron deposition within the substantia nigra is further increased, contributing to a heightened pro-oxidant environment in dopaminergic neurons. We hypothesise that individuals in high-income countries, where cereals and...

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Autores principales:	Dominic J Hare, Bárbara Rita Cardoso, Erika P Raven, Kay L Double, David I Finkelstein, Ewa A Szymlek-Gay, Beverley-Ann Biggs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f22c5328fdf74dc0b1ae3c8bb9fca3a3
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spelling	oai:doaj.org-article:f22c5328fdf74dc0b1ae3c8bb9fca3a32021-12-02T12:33:37ZExcessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease10.1038/s41531-016-0004-y2373-8057https://doaj.org/article/f22c5328fdf74dc0b1ae3c8bb9fca3a32017-01-01T00:00:00Zhttps://doi.org/10.1038/s41531-016-0004-yhttps://doaj.org/toc/2373-8057Abstract Iron accumulates gradually in the ageing brain. In Parkinson’s disease, iron deposition within the substantia nigra is further increased, contributing to a heightened pro-oxidant environment in dopaminergic neurons. We hypothesise that individuals in high-income countries, where cereals and infant formulae have historically been fortified with iron, experience increased early-life iron exposure that predisposes them to age-related iron accumulation in the brain. Combined with genetic factors that limit iron regulatory capacity and/or dopamine metabolism, this may increase the risk of Parkinson’s diseases. We propose to (a) validate a retrospective biomarker of iron exposure in children; (b) translate this biomarker to adults; (c) integrate it with in vivo brain iron in Parkinson’s disease; and (d) longitudinally examine the relationships between early-life iron exposure and metabolism, brain iron deposition and Parkinson’s disease risk. This approach will provide empirical evidence to support therapeutically addressing brain iron deposition in Parkinson’s diseases and produce a potential biomarker of Parkinson’s disease risk in preclinical individuals.Dominic J HareBárbara Rita CardosoErika P RavenKay L DoubleDavid I FinkelsteinEwa A Szymlek-GayBeverley-Ann BiggsNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 3, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Dominic J Hare Bárbara Rita Cardoso Erika P Raven Kay L Double David I Finkelstein Ewa A Szymlek-Gay Beverley-Ann Biggs Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease
description	Abstract Iron accumulates gradually in the ageing brain. In Parkinson’s disease, iron deposition within the substantia nigra is further increased, contributing to a heightened pro-oxidant environment in dopaminergic neurons. We hypothesise that individuals in high-income countries, where cereals and infant formulae have historically been fortified with iron, experience increased early-life iron exposure that predisposes them to age-related iron accumulation in the brain. Combined with genetic factors that limit iron regulatory capacity and/or dopamine metabolism, this may increase the risk of Parkinson’s diseases. We propose to (a) validate a retrospective biomarker of iron exposure in children; (b) translate this biomarker to adults; (c) integrate it with in vivo brain iron in Parkinson’s disease; and (d) longitudinally examine the relationships between early-life iron exposure and metabolism, brain iron deposition and Parkinson’s disease risk. This approach will provide empirical evidence to support therapeutically addressing brain iron deposition in Parkinson’s diseases and produce a potential biomarker of Parkinson’s disease risk in preclinical individuals.
format	article
author	Dominic J Hare Bárbara Rita Cardoso Erika P Raven Kay L Double David I Finkelstein Ewa A Szymlek-Gay Beverley-Ann Biggs
author_facet	Dominic J Hare Bárbara Rita Cardoso Erika P Raven Kay L Double David I Finkelstein Ewa A Szymlek-Gay Beverley-Ann Biggs
author_sort	Dominic J Hare
title	Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease
title_short	Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease
title_full	Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease
title_fullStr	Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease
title_full_unstemmed	Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease
title_sort	excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for parkinson’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f22c5328fdf74dc0b1ae3c8bb9fca3a3
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Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson’s disease

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