Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells

Small molecule inhibitors can influence the choice of repair pathways, enhancing nucleotide substitution and gene integration in CRISPR-mediated genome editing. Here the authors introduce CRISPY, a mix of small molecules that can enhance precise editing with Cpf1 and Cas9D10A in hiPSCs.

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Autores principales: Stephan Riesenberg, Tomislav Maricic
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/f237a600df754fcf880c21624126704e
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