Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells

Small molecule inhibitors can influence the choice of repair pathways, enhancing nucleotide substitution and gene integration in CRISPR-mediated genome editing. Here the authors introduce CRISPY, a mix of small molecules that can enhance precise editing with Cpf1 and Cas9D10A in hiPSCs.

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Detalles Bibliográficos
Autores principales:	Stephan Riesenberg, Tomislav Maricic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f237a600df754fcf880c21624126704e
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spelling	oai:doaj.org-article:f237a600df754fcf880c21624126704e2021-12-02T14:40:55ZTargeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells10.1038/s41467-018-04609-72041-1723https://doaj.org/article/f237a600df754fcf880c21624126704e2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04609-7https://doaj.org/toc/2041-1723Small molecule inhibitors can influence the choice of repair pathways, enhancing nucleotide substitution and gene integration in CRISPR-mediated genome editing. Here the authors introduce CRISPY, a mix of small molecules that can enhance precise editing with Cpf1 and Cas9D10A in hiPSCs.Stephan RiesenbergTomislav MaricicNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephan Riesenberg Tomislav Maricic Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells
description	Small molecule inhibitors can influence the choice of repair pathways, enhancing nucleotide substitution and gene integration in CRISPR-mediated genome editing. Here the authors introduce CRISPY, a mix of small molecules that can enhance precise editing with Cpf1 and Cas9D10A in hiPSCs.
format	article
author	Stephan Riesenberg Tomislav Maricic
author_facet	Stephan Riesenberg Tomislav Maricic
author_sort	Stephan Riesenberg
title	Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells
title_short	Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells
title_full	Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells
title_fullStr	Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells
title_full_unstemmed	Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells
title_sort	targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f237a600df754fcf880c21624126704e
work_keys_str_mv	AT stephanriesenberg targetingrepairpathwayswithsmallmoleculesincreasesprecisegenomeeditinginpluripotentstemcells AT tomislavmaricic targetingrepairpathwayswithsmallmoleculesincreasesprecisegenomeeditinginpluripotentstemcells
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Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells

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