The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress

Changes in chromatin structure have been linked to organismal ageing. Here the authors show that altered histone expression and mitochondrial stress during C. elegans development result in chromatin changes and a cytosolic stress response that affects organismal longevity, and depends on HSF-1 and t...

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Autores principales:	Olli Matilainen, Maroun S. Bou Sleiman, Pedro M. Quiros, Susana M. D. A. Garcia, Johan Auwerx
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f2448e82fe1a47ca8ebd24b4a5a05de3
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id	oai:doaj.org-article:f2448e82fe1a47ca8ebd24b4a5a05de3
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spelling	oai:doaj.org-article:f2448e82fe1a47ca8ebd24b4a5a05de32021-12-02T17:06:20ZThe chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress10.1038/s41467-017-01903-82041-1723https://doaj.org/article/f2448e82fe1a47ca8ebd24b4a5a05de32017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01903-8https://doaj.org/toc/2041-1723Changes in chromatin structure have been linked to organismal ageing. Here the authors show that altered histone expression and mitochondrial stress during C. elegans development result in chromatin changes and a cytosolic stress response that affects organismal longevity, and depends on HSF-1 and the chromatin remodeller, ISW-1.Olli MatilainenMaroun S. Bou SleimanPedro M. QuirosSusana M. D. A. GarciaJohan AuwerxNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Olli Matilainen Maroun S. Bou Sleiman Pedro M. Quiros Susana M. D. A. Garcia Johan Auwerx The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress
description	Changes in chromatin structure have been linked to organismal ageing. Here the authors show that altered histone expression and mitochondrial stress during C. elegans development result in chromatin changes and a cytosolic stress response that affects organismal longevity, and depends on HSF-1 and the chromatin remodeller, ISW-1.
format	article
author	Olli Matilainen Maroun S. Bou Sleiman Pedro M. Quiros Susana M. D. A. Garcia Johan Auwerx
author_facet	Olli Matilainen Maroun S. Bou Sleiman Pedro M. Quiros Susana M. D. A. Garcia Johan Auwerx
author_sort	Olli Matilainen
title	The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress
title_short	The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress
title_full	The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress
title_fullStr	The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress
title_full_unstemmed	The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress
title_sort	chromatin remodeling factor isw-1 integrates organismal responses against nuclear and mitochondrial stress
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f2448e82fe1a47ca8ebd24b4a5a05de3
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The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress

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