Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling

Abstract We propose a new mechanism of sensory modulation through cutaneous dopaminergic signalling. We hypothesize that dopaminergic signalling contributes to differential cutaneous sensitivity in darker versus lighter pigmented humans and mouse strains. We show that thermal and mechanical cutaneou...

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Autores principales:	Kentaro Ono, Chi T. Viet, Yi Ye, Dongmin Dang, Suzuro Hitomi, Takashi Toyono, Kiyotoshi Inenaga, John C. Dolan, Brian L. Schmidt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f252b43606194cc794164521730b225d
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spelling	oai:doaj.org-article:f252b43606194cc794164521730b225d2021-12-02T12:31:51ZCutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling10.1038/s41598-017-09682-42045-2322https://doaj.org/article/f252b43606194cc794164521730b225d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09682-4https://doaj.org/toc/2045-2322Abstract We propose a new mechanism of sensory modulation through cutaneous dopaminergic signalling. We hypothesize that dopaminergic signalling contributes to differential cutaneous sensitivity in darker versus lighter pigmented humans and mouse strains. We show that thermal and mechanical cutaneous sensitivity is pigmentation dependent. Meta-analyses in humans and mice, along with our own mouse behavioural studies, reveal higher thermal sensitivity in pigmented skin relative to less-pigmented or albino skin. We show that dopamine from melanocytes activates the D1-like dopamine receptor on primary sensory neurons. Dopaminergic activation increases expression of the heat-sensitive TRPV1 ion channel and reduces expression of the mechanically-sensitive Piezo2 channel; thermal threshold is lower and mechanical threshold is higher in pigmented skin.Kentaro OnoChi T. VietYi YeDongmin DangSuzuro HitomiTakashi ToyonoKiyotoshi InenagaJohn C. DolanBrian L. SchmidtNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kentaro Ono Chi T. Viet Yi Ye Dongmin Dang Suzuro Hitomi Takashi Toyono Kiyotoshi Inenaga John C. Dolan Brian L. Schmidt Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling
description	Abstract We propose a new mechanism of sensory modulation through cutaneous dopaminergic signalling. We hypothesize that dopaminergic signalling contributes to differential cutaneous sensitivity in darker versus lighter pigmented humans and mouse strains. We show that thermal and mechanical cutaneous sensitivity is pigmentation dependent. Meta-analyses in humans and mice, along with our own mouse behavioural studies, reveal higher thermal sensitivity in pigmented skin relative to less-pigmented or albino skin. We show that dopamine from melanocytes activates the D1-like dopamine receptor on primary sensory neurons. Dopaminergic activation increases expression of the heat-sensitive TRPV1 ion channel and reduces expression of the mechanically-sensitive Piezo2 channel; thermal threshold is lower and mechanical threshold is higher in pigmented skin.
format	article
author	Kentaro Ono Chi T. Viet Yi Ye Dongmin Dang Suzuro Hitomi Takashi Toyono Kiyotoshi Inenaga John C. Dolan Brian L. Schmidt
author_facet	Kentaro Ono Chi T. Viet Yi Ye Dongmin Dang Suzuro Hitomi Takashi Toyono Kiyotoshi Inenaga John C. Dolan Brian L. Schmidt
author_sort	Kentaro Ono
title	Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling
title_short	Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling
title_full	Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling
title_fullStr	Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling
title_full_unstemmed	Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling
title_sort	cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f252b43606194cc794164521730b225d
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Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling

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