A genetically stable Zika virus vaccine candidate protects mice against virus infection and vertical transmission

A genetically stable Zika virus vaccine candidate protects mice against virus infection and vertical transmission

Abstract Although live attenuated vaccines (LAVs) have been effective in the control of flavivirus infections, to date they have been excluded from Zika virus (ZIKV) vaccine trials due to safety concerns. We have previously reported two ZIKV mutants, each of which has a single substitution in either...

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Détails bibliographiques
Auteurs principaux: Awadalkareem Adam, Camila R. Fontes-Garfias, Vanessa V. Sarathy, Yang Liu, Huanle Luo, Emily Davis, Wenqian Li, Antonio E. Muruato, Binbin Wang, Renat Ahatov, Yoseph Mahmoud, Chao Shan, Samantha R. Osman, Steven G. Widen, Alan D. T. Barrett, Pei-Yong Shi, Tian Wang
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Immunologic diseases. Allergy
RC581-607
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Accès en ligne:https://doaj.org/article/f28c37c48ce34bfaad88626bc97d5974
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https://doaj.org/article/f28c37c48ce34bfaad88626bc97d5974

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