Ligand binding modes from low resolution GPCR models and mutagenesis: chicken bitter taste receptor as a test-case

Ligand binding modes from low resolution GPCR models and mutagenesis: chicken bitter taste receptor as a test-case

Abstract Bitter taste is one of the basic taste modalities, warning against consuming potential poisons. Bitter compounds activate members of the bitter taste receptor (Tas2r) subfamily of G protein-coupled receptors (GPCRs). The number of functional Tas2rs is species-dependent. Chickens represent a...

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Main Authors: Antonella Di Pizio, Louisa-Marie Kruetzfeldt, Shira Cheled-Shoval, Wolfgang Meyerhof, Maik Behrens, Masha Y. Niv
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/f2c51f37776d4a93b2eea86820a84d7a
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