The effects of beta-cell mass and function, intercellular coupling, and islet synchrony on $${\text {Ca}}^{2+}$$ Ca 2 + dynamics

Abstract Type 2 diabetes (T2D) is a challenging metabolic disorder characterized by a substantial loss of $$\beta $$ β -cell mass and alteration of $$\beta $$ β -cell function in the islets of Langerhans, disrupting insulin secretion and glucose homeostasis. The mechanisms for deficiency in $$\beta...

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Autores principales: Maryam Saadati, Yousef Jamali
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f2c53237365148c787b151a405366822
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