An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria.

An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria.

Cerebral malaria (CM) is a lethal neurological complication of malaria. We implemented a genome-wide screen in mutagenized mice to identify host proteins involved in CM pathogenesis and whose inhibition may be of therapeutic value. One pedigree (P48) segregated a resistance trait whose CM-protective...

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Autores principales: Silayuv E Bongfen, Ian-Gael Rodrigue-Gervais, Joanne Berghout, Sabrina Torre, Pablo Cingolani, Sean A Wiltshire, Gabriel A Leiva-Torres, Louis Letourneau, Robert Sladek, Mathieu Blanchette, Mark Lathrop, Marcel A Behr, Samantha Gruenheid, Silvia M Vidal, Maya Saleh, Philippe Gros
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/f2ebc22ce44b429ab6dc2ed68254a468
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https://doaj.org/article/f2ebc22ce44b429ab6dc2ed68254a468

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