Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

Demethoxyviridin is a fungal steroid that inhibits a phosphatidylinositol 3-kinase, an enzyme contributing to tumor progression. Here, the authors elucidate the biosynthetic route that leads to the formation of demethoxyviridin in fungi.

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Autores principales:	Gao-Qian Wang, Guo-Dong Chen, Sheng-Ying Qin, Dan Hu, Takayoshi Awakawa, Shao-Yang Li, Jian-Ming Lv, Chuan-Xi Wang, Xin-Sheng Yao, Ikuro Abe, Hao Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f30a4248c8d1480983d411fc8c04ad53
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spelling	oai:doaj.org-article:f30a4248c8d1480983d411fc8c04ad532021-12-02T16:50:11ZBiosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage10.1038/s41467-018-04298-22041-1723https://doaj.org/article/f30a4248c8d1480983d411fc8c04ad532018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04298-2https://doaj.org/toc/2041-1723Demethoxyviridin is a fungal steroid that inhibits a phosphatidylinositol 3-kinase, an enzyme contributing to tumor progression. Here, the authors elucidate the biosynthetic route that leads to the formation of demethoxyviridin in fungi.Gao-Qian WangGuo-Dong ChenSheng-Ying QinDan HuTakayoshi AwakawaShao-Yang LiJian-Ming LvChuan-Xi WangXin-Sheng YaoIkuro AbeHao GaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gao-Qian Wang Guo-Dong Chen Sheng-Ying Qin Dan Hu Takayoshi Awakawa Shao-Yang Li Jian-Ming Lv Chuan-Xi Wang Xin-Sheng Yao Ikuro Abe Hao Gao Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
description	Demethoxyviridin is a fungal steroid that inhibits a phosphatidylinositol 3-kinase, an enzyme contributing to tumor progression. Here, the authors elucidate the biosynthetic route that leads to the formation of demethoxyviridin in fungi.
format	article
author	Gao-Qian Wang Guo-Dong Chen Sheng-Ying Qin Dan Hu Takayoshi Awakawa Shao-Yang Li Jian-Ming Lv Chuan-Xi Wang Xin-Sheng Yao Ikuro Abe Hao Gao
author_facet	Gao-Qian Wang Guo-Dong Chen Sheng-Ying Qin Dan Hu Takayoshi Awakawa Shao-Yang Li Jian-Ming Lv Chuan-Xi Wang Xin-Sheng Yao Ikuro Abe Hao Gao
author_sort	Gao-Qian Wang
title	Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
title_short	Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
title_full	Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
title_fullStr	Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
title_full_unstemmed	Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
title_sort	biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f30a4248c8d1480983d411fc8c04ad53
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Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

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