Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer

The connection between DNA replication timing and changes that occur to the epigenome in cancer are still poorly understood. Here, the authors perform Repli-Seq and integrated epigenome analyses and find that genomic regions that undergo long-range epigenetic deregulation in prostate cancer also sho...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qian Du, Saul A. Bert, Nicola J. Armstrong, C. Elizabeth Caldon, Jenny Z. Song, Shalima S. Nair, Cathryn M. Gould, Phuc-Loi Luu, Timothy Peters, Amanda Khoury, Wenjia Qu, Elena Zotenko, Clare Stirzaker, Susan J. Clark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f30c03fec77743c982eea9100fa0daca
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f30c03fec77743c982eea9100fa0daca
record_format	dspace
spelling	oai:doaj.org-article:f30c03fec77743c982eea9100fa0daca2021-12-02T15:35:18ZReplication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer10.1038/s41467-019-08302-12041-1723https://doaj.org/article/f30c03fec77743c982eea9100fa0daca2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08302-1https://doaj.org/toc/2041-1723The connection between DNA replication timing and changes that occur to the epigenome in cancer are still poorly understood. Here, the authors perform Repli-Seq and integrated epigenome analyses and find that genomic regions that undergo long-range epigenetic deregulation in prostate cancer also show concordant differences in replication timing.Qian DuSaul A. BertNicola J. ArmstrongC. Elizabeth CaldonJenny Z. SongShalima S. NairCathryn M. GouldPhuc-Loi LuuTimothy PetersAmanda KhouryWenjia QuElena ZotenkoClare StirzakerSusan J. ClarkNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qian Du Saul A. Bert Nicola J. Armstrong C. Elizabeth Caldon Jenny Z. Song Shalima S. Nair Cathryn M. Gould Phuc-Loi Luu Timothy Peters Amanda Khoury Wenjia Qu Elena Zotenko Clare Stirzaker Susan J. Clark Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer
description	The connection between DNA replication timing and changes that occur to the epigenome in cancer are still poorly understood. Here, the authors perform Repli-Seq and integrated epigenome analyses and find that genomic regions that undergo long-range epigenetic deregulation in prostate cancer also show concordant differences in replication timing.
format	article
author	Qian Du Saul A. Bert Nicola J. Armstrong C. Elizabeth Caldon Jenny Z. Song Shalima S. Nair Cathryn M. Gould Phuc-Loi Luu Timothy Peters Amanda Khoury Wenjia Qu Elena Zotenko Clare Stirzaker Susan J. Clark
author_facet	Qian Du Saul A. Bert Nicola J. Armstrong C. Elizabeth Caldon Jenny Z. Song Shalima S. Nair Cathryn M. Gould Phuc-Loi Luu Timothy Peters Amanda Khoury Wenjia Qu Elena Zotenko Clare Stirzaker Susan J. Clark
author_sort	Qian Du
title	Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer
title_short	Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer
title_full	Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer
title_fullStr	Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer
title_full_unstemmed	Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer
title_sort	replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f30c03fec77743c982eea9100fa0daca
work_keys_str_mv	AT qiandu replicationtimingandepigenomeremodellingareassociatedwiththenatureofchromosomalrearrangementsincancer AT saulabert replicationtimingandepigenomeremodellingareassociatedwiththenatureofchromosomalrearrangementsincancer AT nicolajarmstrong replicationtimingandepigenomeremodellingareassociatedwiththenatureofchromosomalrearrangementsincancer AT celizabethcaldon replicationtimingandepigenomeremodellingareassociatedwiththenatureofchromosomalrearrangementsincancer AT jennyzsong replicationtimingandepigenomeremodellingareassociatedwiththenatureofchromosomalrearrangementsincancer AT shalimasnair replicationtimingandepigenomeremodellingareassociatedwiththenatureofchromosomalrearrangementsincancer AT cathrynmgould replicationtimingandepigenomeremodellingareassociatedwiththenatureofchromosomalrearrangementsincancer AT phucloiluu replicationtimingandepigenomeremodellingareassociatedwiththenatureofchromosomalrearrangementsincancer AT timothypeters replicationtimingandepigenomeremodellingareassociatedwiththenatureofchromosomalrearrangementsincancer AT amandakhoury replicationtimingandepigenomeremodellingareassociatedwiththenatureofchromosomalrearrangementsincancer AT wenjiaqu replicationtimingandepigenomeremodellingareassociatedwiththenatureofchromosomalrearrangementsincancer AT elenazotenko replicationtimingandepigenomeremodellingareassociatedwiththenatureofchromosomalrearrangementsincancer AT clarestirzaker replicationtimingandepigenomeremodellingareassociatedwiththenatureofchromosomalrearrangementsincancer AT susanjclark replicationtimingandepigenomeremodellingareassociatedwiththenatureofchromosomalrearrangementsincancer
_version_	1718386633116483584

Replication timing and epigenome remodelling are associated with the nature of chromosomal rearrangements in cancer

Ejemplares similares