Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in <named-content content-type="genus-species">Escherichia coli</named-content> Bloodstream Isolates

Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in <named-content content-type="genus-species">Escherichia coli</named-content> Bloodstream Isolates

ABSTRACT Infections by multidrug-resistant Gram-negative bacteria are increasingly common, prompting the renewed interest in the use of colistin. Colistin specifically targets Gram-negative bacteria by interacting with the anionic lipid A moieties of lipopolysaccharides, leading to membrane destabil...

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Autores principales: Axel B. Janssen, Toby L. Bartholomew, Natalia P. Marciszewska, Marc J. M. Bonten, Rob J. L. Willems, Jose A. Bengoechea, Willem van Schaik
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
Escherichia coli
antibiotic resistance
colistin
two-component regulatory systems
whole-genome sequencing
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/f3252623321a4b8a8b5cbada519deefc
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