UbiD domain dynamics underpins aromatic decarboxylation

Understanding the structure and dynamics of enzymes is important for a number of applications. Here, the authors report on the crystal structure of vanillic acid decarboxylase, and show how the dynamics of the UbiD superfamily enzymes relate to the covalent catalysis of aromatic (de)carboxylation.

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Autores principales: Stephen A. Marshall, Karl A. P. Payne, Karl Fisher, Gabriel R. Titchiner, Colin Levy, Sam Hay, David Leys
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f32b25ac38ee44d1bc567840faf9b7cd
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spelling oai:doaj.org-article:f32b25ac38ee44d1bc567840faf9b7cd2021-12-02T16:46:37ZUbiD domain dynamics underpins aromatic decarboxylation10.1038/s41467-021-25278-z2041-1723https://doaj.org/article/f32b25ac38ee44d1bc567840faf9b7cd2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25278-zhttps://doaj.org/toc/2041-1723Understanding the structure and dynamics of enzymes is important for a number of applications. Here, the authors report on the crystal structure of vanillic acid decarboxylase, and show how the dynamics of the UbiD superfamily enzymes relate to the covalent catalysis of aromatic (de)carboxylation.Stephen A. MarshallKarl A. P. PayneKarl FisherGabriel R. TitchinerColin LevySam HayDavid LeysNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Stephen A. Marshall
Karl A. P. Payne
Karl Fisher
Gabriel R. Titchiner
Colin Levy
Sam Hay
David Leys
UbiD domain dynamics underpins aromatic decarboxylation
description Understanding the structure and dynamics of enzymes is important for a number of applications. Here, the authors report on the crystal structure of vanillic acid decarboxylase, and show how the dynamics of the UbiD superfamily enzymes relate to the covalent catalysis of aromatic (de)carboxylation.
format article
author Stephen A. Marshall
Karl A. P. Payne
Karl Fisher
Gabriel R. Titchiner
Colin Levy
Sam Hay
David Leys
author_facet Stephen A. Marshall
Karl A. P. Payne
Karl Fisher
Gabriel R. Titchiner
Colin Levy
Sam Hay
David Leys
author_sort Stephen A. Marshall
title UbiD domain dynamics underpins aromatic decarboxylation
title_short UbiD domain dynamics underpins aromatic decarboxylation
title_full UbiD domain dynamics underpins aromatic decarboxylation
title_fullStr UbiD domain dynamics underpins aromatic decarboxylation
title_full_unstemmed UbiD domain dynamics underpins aromatic decarboxylation
title_sort ubid domain dynamics underpins aromatic decarboxylation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/f32b25ac38ee44d1bc567840faf9b7cd
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AT karlappayne ubiddomaindynamicsunderpinsaromaticdecarboxylation
AT karlfisher ubiddomaindynamicsunderpinsaromaticdecarboxylation
AT gabrielrtitchiner ubiddomaindynamicsunderpinsaromaticdecarboxylation
AT colinlevy ubiddomaindynamicsunderpinsaromaticdecarboxylation
AT samhay ubiddomaindynamicsunderpinsaromaticdecarboxylation
AT davidleys ubiddomaindynamicsunderpinsaromaticdecarboxylation
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