UbiD domain dynamics underpins aromatic decarboxylation
Understanding the structure and dynamics of enzymes is important for a number of applications. Here, the authors report on the crystal structure of vanillic acid decarboxylase, and show how the dynamics of the UbiD superfamily enzymes relate to the covalent catalysis of aromatic (de)carboxylation.
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2021
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oai:doaj.org-article:f32b25ac38ee44d1bc567840faf9b7cd2021-12-02T16:46:37ZUbiD domain dynamics underpins aromatic decarboxylation10.1038/s41467-021-25278-z2041-1723https://doaj.org/article/f32b25ac38ee44d1bc567840faf9b7cd2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25278-zhttps://doaj.org/toc/2041-1723Understanding the structure and dynamics of enzymes is important for a number of applications. Here, the authors report on the crystal structure of vanillic acid decarboxylase, and show how the dynamics of the UbiD superfamily enzymes relate to the covalent catalysis of aromatic (de)carboxylation.Stephen A. MarshallKarl A. P. PayneKarl FisherGabriel R. TitchinerColin LevySam HayDavid LeysNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
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Science Q Stephen A. Marshall Karl A. P. Payne Karl Fisher Gabriel R. Titchiner Colin Levy Sam Hay David Leys UbiD domain dynamics underpins aromatic decarboxylation |
description |
Understanding the structure and dynamics of enzymes is important for a number of applications. Here, the authors report on the crystal structure of vanillic acid decarboxylase, and show how the dynamics of the UbiD superfamily enzymes relate to the covalent catalysis of aromatic (de)carboxylation. |
format |
article |
author |
Stephen A. Marshall Karl A. P. Payne Karl Fisher Gabriel R. Titchiner Colin Levy Sam Hay David Leys |
author_facet |
Stephen A. Marshall Karl A. P. Payne Karl Fisher Gabriel R. Titchiner Colin Levy Sam Hay David Leys |
author_sort |
Stephen A. Marshall |
title |
UbiD domain dynamics underpins aromatic decarboxylation |
title_short |
UbiD domain dynamics underpins aromatic decarboxylation |
title_full |
UbiD domain dynamics underpins aromatic decarboxylation |
title_fullStr |
UbiD domain dynamics underpins aromatic decarboxylation |
title_full_unstemmed |
UbiD domain dynamics underpins aromatic decarboxylation |
title_sort |
ubid domain dynamics underpins aromatic decarboxylation |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/f32b25ac38ee44d1bc567840faf9b7cd |
work_keys_str_mv |
AT stephenamarshall ubiddomaindynamicsunderpinsaromaticdecarboxylation AT karlappayne ubiddomaindynamicsunderpinsaromaticdecarboxylation AT karlfisher ubiddomaindynamicsunderpinsaromaticdecarboxylation AT gabrielrtitchiner ubiddomaindynamicsunderpinsaromaticdecarboxylation AT colinlevy ubiddomaindynamicsunderpinsaromaticdecarboxylation AT samhay ubiddomaindynamicsunderpinsaromaticdecarboxylation AT davidleys ubiddomaindynamicsunderpinsaromaticdecarboxylation |
_version_ |
1718383429730435072 |