p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis

p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis

The tumour suppressor p120-catenin (p120) controls cadherin-based adhesion. Here, the authors demonstrate that p120 regulates cytokinesis through binding to the centralspindlin component MKLP1 and controls RhoA activity. Loss of p120 in cancer induces multinucleation and chromosomal instability, ind...

Full description

Saved in:
Bibliographic Details
Main Authors: Robert A.H. van de Ven, Jolien S. de Groot, Danielle Park, Robert van Domselaar, Danielle de Jong, Karoly Szuhai, Elsken van der Wall, Oscar M. Rueda, H. Raza Ali, Carlos Caldas, Paul J. van Diest, Martin W. Hetzer, Erik Sahai, Patrick W.B. Derksen
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/f34cb9a535fd4607bed79e5018991e0c
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/f34cb9a535fd4607bed79e5018991e0c

Similar Items