A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury
Protein kinases have emerged as critical regulators of disease pathogenesis. Here, the authors have utilized kinome-wide screening approaches to reveal a pathogenic role of CDKL5 kinase in acute kidney injury, which is dependent on suppression of a SOX9-associated transcriptional network.
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Nature Portfolio
2020
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oai:doaj.org-article:f36413dcdc0f4c47bbdac00ac1a34b202021-12-02T15:37:14ZA kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury10.1038/s41467-020-15638-62041-1723https://doaj.org/article/f36413dcdc0f4c47bbdac00ac1a34b202020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15638-6https://doaj.org/toc/2041-1723Protein kinases have emerged as critical regulators of disease pathogenesis. Here, the authors have utilized kinome-wide screening approaches to reveal a pathogenic role of CDKL5 kinase in acute kidney injury, which is dependent on suppression of a SOX9-associated transcriptional network.Ji Young KimYuntao BaiLaura A. JayneRalph D. HectorAvinash K. PersaudSu Sien OngShreshtha RojeshRadhika RajMei Ji He Ho FengSangwoon ChungRachel E. CiancioloJohn W. ChristmanMoray J. CampbellDavid S. GardnerSharyn D. BakerAlex SparreboomRajgopal GovindarajanHarpreet SinghTaosheng ChenMing PoiKatalin SusztakStuart R. CobbNavjot Singh PablaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ji Young Kim Yuntao Bai Laura A. Jayne Ralph D. Hector Avinash K. Persaud Su Sien Ong Shreshtha Rojesh Radhika Raj Mei Ji He Ho Feng Sangwoon Chung Rachel E. Cianciolo John W. Christman Moray J. Campbell David S. Gardner Sharyn D. Baker Alex Sparreboom Rajgopal Govindarajan Harpreet Singh Taosheng Chen Ming Poi Katalin Susztak Stuart R. Cobb Navjot Singh Pabla A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury |
| description |
Protein kinases have emerged as critical regulators of disease pathogenesis. Here, the authors have utilized kinome-wide screening approaches to reveal a pathogenic role of CDKL5 kinase in acute kidney injury, which is dependent on suppression of a SOX9-associated transcriptional network. |
| format |
article |
| author |
Ji Young Kim Yuntao Bai Laura A. Jayne Ralph D. Hector Avinash K. Persaud Su Sien Ong Shreshtha Rojesh Radhika Raj Mei Ji He Ho Feng Sangwoon Chung Rachel E. Cianciolo John W. Christman Moray J. Campbell David S. Gardner Sharyn D. Baker Alex Sparreboom Rajgopal Govindarajan Harpreet Singh Taosheng Chen Ming Poi Katalin Susztak Stuart R. Cobb Navjot Singh Pabla |
| author_facet |
Ji Young Kim Yuntao Bai Laura A. Jayne Ralph D. Hector Avinash K. Persaud Su Sien Ong Shreshtha Rojesh Radhika Raj Mei Ji He Ho Feng Sangwoon Chung Rachel E. Cianciolo John W. Christman Moray J. Campbell David S. Gardner Sharyn D. Baker Alex Sparreboom Rajgopal Govindarajan Harpreet Singh Taosheng Chen Ming Poi Katalin Susztak Stuart R. Cobb Navjot Singh Pabla |
| author_sort |
Ji Young Kim |
| title |
A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury |
| title_short |
A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury |
| title_full |
A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury |
| title_fullStr |
A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury |
| title_full_unstemmed |
A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury |
| title_sort |
kinome-wide screen identifies a cdkl5-sox9 regulatory axis in epithelial cell death and kidney injury |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/f36413dcdc0f4c47bbdac00ac1a34b20 |
| work_keys_str_mv |
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