A model of DNA damage response activation at stalled replication forks by SPRTN

The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.

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Autores principales: Christopher Bruhn, Marco Foiani
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/f367c6151ba84697a0a594a8dd42fb3f
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