Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease

To investigate the molecular foundation of sporadic Alzheimer’s disease (AD), Beckmann et al. constructed multiscale causal networks on a large human AD multi-omics dataset, detecting AD-associated networks and their top predicted regulator, VGF, with extensive validation in the 5xFAD mouse model.

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Autores principales:	Noam D. Beckmann, Wei-Jye Lin, Minghui Wang, Ariella T. Cohain, Alexander W. Charney, Pei Wang, Weiping Ma, Ying-Chih Wang, Cheng Jiang, Mickael Audrain, Phillip H. Comella, Amanda K. Fakira, Siddharth P. Hariharan, Gillian M. Belbin, Kiran Girdhar, Allan I. Levey, Nicholas T. Seyfried, Eric B. Dammer, Duc Duong, James J. Lah, Jean-Vianney Haure-Mirande, Ben Shackleton, Tomas Fanutza, Robert Blitzer, Eimear Kenny, Jun Zhu, Vahram Haroutunian, Pavel Katsel, Sam Gandy, Zhidong Tu, Michelle E. Ehrlich, Bin Zhang, Stephen R. Salton, Eric E. Schadt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f3a49830ea0b40449d13d63b2ea4d0a8
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spelling	oai:doaj.org-article:f3a49830ea0b40449d13d63b2ea4d0a82021-12-02T16:35:43ZMultiscale causal networks identify VGF as a key regulator of Alzheimer’s disease10.1038/s41467-020-17405-z2041-1723https://doaj.org/article/f3a49830ea0b40449d13d63b2ea4d0a82020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17405-zhttps://doaj.org/toc/2041-1723To investigate the molecular foundation of sporadic Alzheimer’s disease (AD), Beckmann et al. constructed multiscale causal networks on a large human AD multi-omics dataset, detecting AD-associated networks and their top predicted regulator, VGF, with extensive validation in the 5xFAD mouse model.Noam D. BeckmannWei-Jye LinMinghui WangAriella T. CohainAlexander W. CharneyPei WangWeiping MaYing-Chih WangCheng JiangMickael AudrainPhillip H. ComellaAmanda K. FakiraSiddharth P. HariharanGillian M. BelbinKiran GirdharAllan I. LeveyNicholas T. SeyfriedEric B. DammerDuc DuongJames J. LahJean-Vianney Haure-MirandeBen ShackletonTomas FanutzaRobert BlitzerEimear KennyJun ZhuVahram HaroutunianPavel KatselSam GandyZhidong TuMichelle E. EhrlichBin ZhangStephen R. SaltonEric E. SchadtNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Noam D. Beckmann Wei-Jye Lin Minghui Wang Ariella T. Cohain Alexander W. Charney Pei Wang Weiping Ma Ying-Chih Wang Cheng Jiang Mickael Audrain Phillip H. Comella Amanda K. Fakira Siddharth P. Hariharan Gillian M. Belbin Kiran Girdhar Allan I. Levey Nicholas T. Seyfried Eric B. Dammer Duc Duong James J. Lah Jean-Vianney Haure-Mirande Ben Shackleton Tomas Fanutza Robert Blitzer Eimear Kenny Jun Zhu Vahram Haroutunian Pavel Katsel Sam Gandy Zhidong Tu Michelle E. Ehrlich Bin Zhang Stephen R. Salton Eric E. Schadt Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease
description	To investigate the molecular foundation of sporadic Alzheimer’s disease (AD), Beckmann et al. constructed multiscale causal networks on a large human AD multi-omics dataset, detecting AD-associated networks and their top predicted regulator, VGF, with extensive validation in the 5xFAD mouse model.
format	article
author	Noam D. Beckmann Wei-Jye Lin Minghui Wang Ariella T. Cohain Alexander W. Charney Pei Wang Weiping Ma Ying-Chih Wang Cheng Jiang Mickael Audrain Phillip H. Comella Amanda K. Fakira Siddharth P. Hariharan Gillian M. Belbin Kiran Girdhar Allan I. Levey Nicholas T. Seyfried Eric B. Dammer Duc Duong James J. Lah Jean-Vianney Haure-Mirande Ben Shackleton Tomas Fanutza Robert Blitzer Eimear Kenny Jun Zhu Vahram Haroutunian Pavel Katsel Sam Gandy Zhidong Tu Michelle E. Ehrlich Bin Zhang Stephen R. Salton Eric E. Schadt
author_facet	Noam D. Beckmann Wei-Jye Lin Minghui Wang Ariella T. Cohain Alexander W. Charney Pei Wang Weiping Ma Ying-Chih Wang Cheng Jiang Mickael Audrain Phillip H. Comella Amanda K. Fakira Siddharth P. Hariharan Gillian M. Belbin Kiran Girdhar Allan I. Levey Nicholas T. Seyfried Eric B. Dammer Duc Duong James J. Lah Jean-Vianney Haure-Mirande Ben Shackleton Tomas Fanutza Robert Blitzer Eimear Kenny Jun Zhu Vahram Haroutunian Pavel Katsel Sam Gandy Zhidong Tu Michelle E. Ehrlich Bin Zhang Stephen R. Salton Eric E. Schadt
author_sort	Noam D. Beckmann
title	Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease
title_short	Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease
title_full	Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease
title_fullStr	Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease
title_full_unstemmed	Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease
title_sort	multiscale causal networks identify vgf as a key regulator of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f3a49830ea0b40449d13d63b2ea4d0a8
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Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease

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