The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function
Oftedal et al. generate mice lacking the chaperonin subunit CCT8 in T cells. They find that loss of CCT8 leads to reduced formation of nuclear actin filaments, changes in proteostasis, defective Th2 cell polarization and T cell metabolism and a failed antigenic response to intestinal helminths.
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2021
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/f3b7f22ef77541f089085a26cdea4934 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|