The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function
Oftedal et al. generate mice lacking the chaperonin subunit CCT8 in T cells. They find that loss of CCT8 leads to reduced formation of nuclear actin filaments, changes in proteostasis, defective Th2 cell polarization and T cell metabolism and a failed antigenic response to intestinal helminths.
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Nature Portfolio
2021
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oai:doaj.org-article:f3b7f22ef77541f089085a26cdea49342021-12-02T17:51:20ZThe chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function10.1038/s42003-021-02203-02399-3642https://doaj.org/article/f3b7f22ef77541f089085a26cdea49342021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02203-0https://doaj.org/toc/2399-3642Oftedal et al. generate mice lacking the chaperonin subunit CCT8 in T cells. They find that loss of CCT8 leads to reduced formation of nuclear actin filaments, changes in proteostasis, defective Th2 cell polarization and T cell metabolism and a failed antigenic response to intestinal helminths.Bergithe E. OftedalStefano MaioAdam E. HandelMadeleine P. J. WhiteDuncan HowieSimon DavisNicolas PrevotIoanna A. RotaMary E. DeadmanBenedikt M. KesslerRoman FischerNikolaus S. TredeErdinc SezginRick M. MaizelsGeorg A. HolländerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Bergithe E. Oftedal Stefano Maio Adam E. Handel Madeleine P. J. White Duncan Howie Simon Davis Nicolas Prevot Ioanna A. Rota Mary E. Deadman Benedikt M. Kessler Roman Fischer Nikolaus S. Trede Erdinc Sezgin Rick M. Maizels Georg A. Holländer The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function |
| description |
Oftedal et al. generate mice lacking the chaperonin subunit CCT8 in T cells. They find that loss of CCT8 leads to reduced formation of nuclear actin filaments, changes in proteostasis, defective Th2 cell polarization and T cell metabolism and a failed antigenic response to intestinal helminths. |
| format |
article |
| author |
Bergithe E. Oftedal Stefano Maio Adam E. Handel Madeleine P. J. White Duncan Howie Simon Davis Nicolas Prevot Ioanna A. Rota Mary E. Deadman Benedikt M. Kessler Roman Fischer Nikolaus S. Trede Erdinc Sezgin Rick M. Maizels Georg A. Holländer |
| author_facet |
Bergithe E. Oftedal Stefano Maio Adam E. Handel Madeleine P. J. White Duncan Howie Simon Davis Nicolas Prevot Ioanna A. Rota Mary E. Deadman Benedikt M. Kessler Roman Fischer Nikolaus S. Trede Erdinc Sezgin Rick M. Maizels Georg A. Holländer |
| author_sort |
Bergithe E. Oftedal |
| title |
The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function |
| title_short |
The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function |
| title_full |
The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function |
| title_fullStr |
The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function |
| title_full_unstemmed |
The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function |
| title_sort |
chaperonin cct8 controls proteostasis essential for t cell maturation, selection, and function |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/f3b7f22ef77541f089085a26cdea4934 |
| work_keys_str_mv |
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