EFFECT OF COVID-19 ON LIVER FUNCTION TESTS; RESULT FROM A TERTIARY CARE HOSPITAL IN PAKISTAN

Objective: To determine the changes in liver function tests if any in patients of COVID-19. Study Design: Cross sectional study. Place and Duration of Study: Combined Military Hospital Lahore, from Apr 2020 to Jun 2020. Methodology: A total of 209 confirmed cases of COVID-19 positive by RT-...

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Autores principales:	Rashk e Hinna, Samina Fida, Muhammad Asif Farooq, Asma Asghar, Muhammad Uzair, Talha Rehman Zahid
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	acute respiratory distress syndrome (ards) covid-19 lfts liver function tests non severe mild to moderate disease Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f3bec3f8bf57448f8a2f03a7c98e8482
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spelling	oai:doaj.org-article:f3bec3f8bf57448f8a2f03a7c98e84822021-12-02T14:54:29ZEFFECT OF COVID-19 ON LIVER FUNCTION TESTS; RESULT FROM A TERTIARY CARE HOSPITAL IN PAKISTAN0030-96482411-8842https://doaj.org/article/f3bec3f8bf57448f8a2f03a7c98e84822020-09-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5242https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the changes in liver function tests if any in patients of COVID-19. Study Design: Cross sectional study. Place and Duration of Study: Combined Military Hospital Lahore, from Apr 2020 to Jun 2020. Methodology: A total of 209 confirmed cases of COVID-19 positive by RT-PCR patients presenting to Combined Military Hospital, Lahore were included in the study. Their demographic details were recorded. Patients were grouped into mild- moderate and severe disease groups according to the symptoms, complications and oxygen or ventilation requirements. Liver function tests of all these patients were advised. Results: Amongst confirmed COVID-19 patients, 187 (89.5%) had mild to moderate disease whereas 22 patients (10.5%) had severe disease. Liver test abnormalities were defined as the elevation of the following liver enzymes in serum: ALT >42 U/L, AST >45 U/L, GGT >49 U/L, ALP >300 U/L, albumin<35g/L and total bilirubin (TBIL) >17.1. In LFTs, Bilirubin was increased in 20 (9.6%) patients), ALT in 32 (15.3%) patients, of which 8 had severe disease, 38 patients having high AST levels (>45) 28 had mild-moderate disease and 10 had severe disease. ALP was raised in 24 (11.5%) patients with 8 being in severe disease and rest in mild moderate disease. Albumin was low in 35 (16.7%) patients of which 12 had severe disease and 23 had mild-moderate disease. Conclusion: About 15-20% of the confirmed cases of COVID-19 have deranged liver function tests and it correlates with severity of the disease. Rashk e HinnaSamina FidaMuhammad Asif FarooqAsma AsgharMuhammad UzairTalha Rehman ZahidArmy Medical College Rawalpindiarticleacute respiratory distress syndrome (ards)covid-19lftsliver function testsnon severemild to moderate diseaseMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 2, Pp 513-517 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute respiratory distress syndrome (ards) covid-19 lfts liver function tests non severe mild to moderate disease Medicine R Medicine (General) R5-920
spellingShingle	acute respiratory distress syndrome (ards) covid-19 lfts liver function tests non severe mild to moderate disease Medicine R Medicine (General) R5-920 Rashk e Hinna Samina Fida Muhammad Asif Farooq Asma Asghar Muhammad Uzair Talha Rehman Zahid EFFECT OF COVID-19 ON LIVER FUNCTION TESTS; RESULT FROM A TERTIARY CARE HOSPITAL IN PAKISTAN
description	Objective: To determine the changes in liver function tests if any in patients of COVID-19. Study Design: Cross sectional study. Place and Duration of Study: Combined Military Hospital Lahore, from Apr 2020 to Jun 2020. Methodology: A total of 209 confirmed cases of COVID-19 positive by RT-PCR patients presenting to Combined Military Hospital, Lahore were included in the study. Their demographic details were recorded. Patients were grouped into mild- moderate and severe disease groups according to the symptoms, complications and oxygen or ventilation requirements. Liver function tests of all these patients were advised. Results: Amongst confirmed COVID-19 patients, 187 (89.5%) had mild to moderate disease whereas 22 patients (10.5%) had severe disease. Liver test abnormalities were defined as the elevation of the following liver enzymes in serum: ALT >42 U/L, AST >45 U/L, GGT >49 U/L, ALP >300 U/L, albumin<35g/L and total bilirubin (TBIL) >17.1. In LFTs, Bilirubin was increased in 20 (9.6%) patients), ALT in 32 (15.3%) patients, of which 8 had severe disease, 38 patients having high AST levels (>45) 28 had mild-moderate disease and 10 had severe disease. ALP was raised in 24 (11.5%) patients with 8 being in severe disease and rest in mild moderate disease. Albumin was low in 35 (16.7%) patients of which 12 had severe disease and 23 had mild-moderate disease. Conclusion: About 15-20% of the confirmed cases of COVID-19 have deranged liver function tests and it correlates with severity of the disease.
format	article
author	Rashk e Hinna Samina Fida Muhammad Asif Farooq Asma Asghar Muhammad Uzair Talha Rehman Zahid
author_facet	Rashk e Hinna Samina Fida Muhammad Asif Farooq Asma Asghar Muhammad Uzair Talha Rehman Zahid
author_sort	Rashk e Hinna
title	EFFECT OF COVID-19 ON LIVER FUNCTION TESTS; RESULT FROM A TERTIARY CARE HOSPITAL IN PAKISTAN
title_short	EFFECT OF COVID-19 ON LIVER FUNCTION TESTS; RESULT FROM A TERTIARY CARE HOSPITAL IN PAKISTAN
title_full	EFFECT OF COVID-19 ON LIVER FUNCTION TESTS; RESULT FROM A TERTIARY CARE HOSPITAL IN PAKISTAN
title_fullStr	EFFECT OF COVID-19 ON LIVER FUNCTION TESTS; RESULT FROM A TERTIARY CARE HOSPITAL IN PAKISTAN
title_full_unstemmed	EFFECT OF COVID-19 ON LIVER FUNCTION TESTS; RESULT FROM A TERTIARY CARE HOSPITAL IN PAKISTAN
title_sort	effect of covid-19 on liver function tests; result from a tertiary care hospital in pakistan
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/f3bec3f8bf57448f8a2f03a7c98e8482
work_keys_str_mv	AT rashkehinna effectofcovid19onliverfunctiontestsresultfromatertiarycarehospitalinpakistan AT saminafida effectofcovid19onliverfunctiontestsresultfromatertiarycarehospitalinpakistan AT muhammadasiffarooq effectofcovid19onliverfunctiontestsresultfromatertiarycarehospitalinpakistan AT asmaasghar effectofcovid19onliverfunctiontestsresultfromatertiarycarehospitalinpakistan AT muhammaduzair effectofcovid19onliverfunctiontestsresultfromatertiarycarehospitalinpakistan AT talharehmanzahid effectofcovid19onliverfunctiontestsresultfromatertiarycarehospitalinpakistan
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EFFECT OF COVID-19 ON LIVER FUNCTION TESTS; RESULT FROM A TERTIARY CARE HOSPITAL IN PAKISTAN

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