High frequency targeted mutagenesis using engineered endonucleases and DNA-end processing enzymes.
Targeting DNA double-strand breaks is a powerful strategy for gene inactivation applications. Without the use of a repair plasmid, targeted mutagenesis can be achieved through Non-Homologous End joining (NHEJ) pathways. However, many of the DNA breaks produced by engineered nucleases may be subject...
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Public Library of Science (PLoS)
2013
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/f3cd0e8d8ff24ecf88c47733d9ec4918 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|