Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

The oncogene MLL is frequently translocated in leukemia, resulting in oncogenic fusion proteins. Here, the authors report a temporally controlled mouse model of MLL-ENL driven leukemia AND identify therapeutic targets associated with early MLL-ENL driven leukaemogenesis.

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Autores principales:	Silvia Basilico, Xiaonan Wang, Alison Kennedy, Konstantinos Tzelepis, George Giotopoulos, Sarah J. Kinston, Pedro M. Quiros, Kim Wong, David J. Adams, Larissa S. Carnevalli, Brian J. P. Huntly, George S. Vassiliou, Fernando J. Calero-Nieto, Berthold Göttgens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f3f11e1f04f14988aa6abc97b3c99275
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spelling	oai:doaj.org-article:f3f11e1f04f14988aa6abc97b3c992752021-12-02T16:49:46ZDissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML10.1038/s41467-020-15220-02041-1723https://doaj.org/article/f3f11e1f04f14988aa6abc97b3c992752020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15220-0https://doaj.org/toc/2041-1723The oncogene MLL is frequently translocated in leukemia, resulting in oncogenic fusion proteins. Here, the authors report a temporally controlled mouse model of MLL-ENL driven leukemia AND identify therapeutic targets associated with early MLL-ENL driven leukaemogenesis.Silvia BasilicoXiaonan WangAlison KennedyKonstantinos TzelepisGeorge GiotopoulosSarah J. KinstonPedro M. QuirosKim WongDavid J. AdamsLarissa S. CarnevalliBrian J. P. HuntlyGeorge S. VassiliouFernando J. Calero-NietoBerthold GöttgensNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Silvia Basilico Xiaonan Wang Alison Kennedy Konstantinos Tzelepis George Giotopoulos Sarah J. Kinston Pedro M. Quiros Kim Wong David J. Adams Larissa S. Carnevalli Brian J. P. Huntly George S. Vassiliou Fernando J. Calero-Nieto Berthold Göttgens Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
description	The oncogene MLL is frequently translocated in leukemia, resulting in oncogenic fusion proteins. Here, the authors report a temporally controlled mouse model of MLL-ENL driven leukemia AND identify therapeutic targets associated with early MLL-ENL driven leukaemogenesis.
format	article
author	Silvia Basilico Xiaonan Wang Alison Kennedy Konstantinos Tzelepis George Giotopoulos Sarah J. Kinston Pedro M. Quiros Kim Wong David J. Adams Larissa S. Carnevalli Brian J. P. Huntly George S. Vassiliou Fernando J. Calero-Nieto Berthold Göttgens
author_facet	Silvia Basilico Xiaonan Wang Alison Kennedy Konstantinos Tzelepis George Giotopoulos Sarah J. Kinston Pedro M. Quiros Kim Wong David J. Adams Larissa S. Carnevalli Brian J. P. Huntly George S. Vassiliou Fernando J. Calero-Nieto Berthold Göttgens
author_sort	Silvia Basilico
title	Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
title_short	Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
title_full	Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
title_fullStr	Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
title_full_unstemmed	Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
title_sort	dissecting the early steps of mll induced leukaemogenic transformation using a mouse model of aml
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f3f11e1f04f14988aa6abc97b3c99275
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Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

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